Background Rotaviruses are nonenveloped RNA viruses belonging to the Reoviridae family.
The viral nucleocapsid is composed of 3 concentric shells that enclose 11 segments of …

A safe and effective rotavirus vaccine is urgently needed, particularly in developing
countries. Critical to vaccine development and implementation is a knowledge base …

This supplement is devoted to 20 papers from the Fifth Rotavirus Vaccine Workshop held in
Atlanta, Georgia, USA, on 16-17 October 1995. The following topics are covered …

Rotavirus was first isolated in 1973 in Australia from children with diarrhea. Hundreds of
thousands of children die annually in developing countries from this virus with the mortality …

The classification of rotaviruses as well as the pathogenesis and the diagnosis of rotavirus
infections are briefly reviewed. Treatment of rotavirus disease consists mainly of oral or …

The twin objectives of all vaccines are safety and efficacy. In the case of rotavirus vaccine for
humans, safety and efficacy initially was sought through oral administration of related …

Rotaviruses are generally species-specific, but cross-species transmission is possible, as
has been demonstrated experimentally. Several case studies have indicated infection of …

The first candidate rotavirus vaccine was a live attenuated oral vaccine made by the
classical empirical method of serial passage of virus in tissue culture cells. Current …

Rotaviruses are the major cause of severe gastroenteritis in young children and animals.
The rotavirus genome is composed of eleven segments of double-stranded RNA and can …

The Fifth Rotavirus Vaccine Workshop, held at the Centers for Disease Control and
Prevention (CDC) 16-17 October 1995, was attended by> 100 scientists from government …