The role of actively released fibrin-conjugated VEGF for VEGF receptor 2 gene activation and the enhancement of angiogenesis
M Ehrbar, SM Zeisberger, GP Raeber, JA Hubbell… - Biomaterials, 2008 - Elsevier
A major challenge for therapeutic delivery of angiogenic agents such as vascular
endothelial growth factor (VEGF) is to achieve sustained, low dose signaling leading to …
endothelial growth factor (VEGF) is to achieve sustained, low dose signaling leading to …
Cell-Demanded Liberation of VEGF121 From Fibrin Implants Induces Local and Controlled Blood Vessel Growth
M Ehrbar, VG Djonov, C Schnell, SA Tschanz… - Circulation …, 2004 - Am Heart Assoc
Although vascular endothelial growth factor (VEGF) has been described as a potent
angiogenic stimulus, its application in therapy remains difficult: blood vessels formed by …
angiogenic stimulus, its application in therapy remains difficult: blood vessels formed by …
The promotion of endothelial cell attachment and spreading using FNIII10 fused to VEGF-A165
S Traub, J Morgner, MM Martino, S Höning, MA Swartz… - Biomaterials, 2013 - Elsevier
Synergy in the downstream signaling pathways of the vascular endothelial growth factor
receptor-2 (VEGFR-2) and the integrin αvβ3 is critical for blood vessel formation. Thus …
receptor-2 (VEGFR-2) and the integrin αvβ3 is critical for blood vessel formation. Thus …
Long-lasting fibrin matrices ensure stable and functional angiogenesis by highly tunable, sustained delivery of recombinant VEGF164
V Sacchi, R Mittermayr, J Hartinger… - Proceedings of the …, 2014 - National Acad Sciences
Clinical trials of therapeutic angiogenesis by vascular endothelial growth factor (VEGF) gene
delivery failed to show efficacy. Major challenges include the need to precisely control in …
delivery failed to show efficacy. Major challenges include the need to precisely control in …
Covalently conjugated VEGF–fibrin matrices for endothelialization
AH Zisch, U Schenk, JC Schense… - Journal of Controlled …, 2001 - Elsevier
Vascular endothelial growth factor (VEGF) is a key factor in endothelial cell biology and
blood vessel formation and a candidate therapeutic for the stimulation of angiogenesis …
blood vessel formation and a candidate therapeutic for the stimulation of angiogenesis …
Endothelial cell proliferation and progenitor maturation by fibrin-bound VEGF variants with differential susceptibilities to local cellular activity
M Ehrbar, A Metters, P Zammaretti, JA Hubbell… - Journal of controlled …, 2005 - Elsevier
A number of vascular therapies could benefit from advanced methods for presentation of
angiogenic growth factors, including growth of endothelium on small caliber vascular grafts …
angiogenic growth factors, including growth of endothelium on small caliber vascular grafts …
VEGF internalization is not required for VEGFR-2 phosphorylation in bioengineered surfaces with covalently linked VEGF
SM Anderson, B Shergill, ZT Barry… - Integrative …, 2011 - academic.oup.com
Vascular endothelial growth factor (VEGF) is known to activate proliferation, migration, and
survival pathways in endothelial cells through phosphorylation of VEGF receptor-2 (VEGFR …
survival pathways in endothelial cells through phosphorylation of VEGF receptor-2 (VEGFR …
Sustained (rh)VEGF165 release from a sprayed fibrin biomatrix induces angiogenesis, up‐regulation of endogenous VEGF‐R2, and reduces ischemic flap necrosis
R Mittermayr, T Morton, M Hofmann… - Wound repair and …, 2008 - Wiley Online Library
This study investigated (1) the release of recombinant human vascular endothelial growth
factor ([rh] VEGF165) from an in vitro fibrin matrix,(2) the effects of (rh) VEGF165 released …
factor ([rh] VEGF165) from an in vitro fibrin matrix,(2) the effects of (rh) VEGF165 released …
Expression of VEGF receptors in arteries after endothelial injury and lack of increased endothelial regrowth in response to VEGF
V Lindner, MA Reidy - Arteriosclerosis, thrombosis, and vascular …, 1996 - Am Heart Assoc
Vascular endothelial growth factor (VEGF) is an endothelial cell–specific factor with
angiogenic effects in vivo and mitogenic effects in vitro. Administration of VEGF has been …
angiogenic effects in vivo and mitogenic effects in vitro. Administration of VEGF has been …
[HTML][HTML] Microenvironmental VEGF concentration, not total dose, determines a threshold between normal and aberrant angiogenesis
CR Ozawa, A Banfi, NL Glazer… - The Journal of …, 2004 - Am Soc Clin Investig
Use of long-term constitutive expression of VEGF for therapeutic angiogenesis may be
limited by the growth of abnormal blood vessels and hemangiomas. We investigated the …
limited by the growth of abnormal blood vessels and hemangiomas. We investigated the …