In vitro studies have demonstrated that the binding of urokinase-type plasminogen activator
(uPA) to its cell surface receptor (uPAR) greatly accelerates plasminogen activation …

Interaction between the urokinase-type plasminogen activator (uPA) and its receptor (uPAR)
localizes cellular proteolysis and promotes cellular proliferation and migration. The …

The urokinase-type plasminogen activator (uPA) interacts with its receptor (uPAR) to
promote local proteolysis as well as cellular proliferation and migration. These functions …

Binding of urokinase-type plasminogen activator (uPA) to a specific receptor (uPAR) on
human lung fibroblasts enables it to regulate cellular proteolysis and remodeling of the …

Human alveolar macrophages are known to synthesize urokinase (uPA) and a specific
plasminogen activator inhibitor, PAI-2. In this study we have identified a uPA receptor …

The role of urokinase-type plasminogen activator (uPA) and its receptor (uPAR) in
fibrinolysis remains unsettled. The contribution of uPA may depend on the vascular location …

The plasminogen/plasmin system, urokinase-type plasminogen activator (uPA), its receptor
(uPAR), and its inhibitor (PAI-1), influence extracellular proteolysis and cell migration in lung …

The urokinase receptor (uPAR) influences several biological functions relevant to lung injury
and repair, including proteolysis, cell migration, and adhesion. In malignant mesothelioma …

Studies from our laboratory have shown that exposure of human lung epithelial cells to
urokinase plasminogen activator (uPA) induces their proliferation. This effect of uPA is likely …

Background Expression of the urokinase plasminogen activator receptor (UPAR) has been
shown to have clinical relevance in various cancers. We have recently identified UPAR as …