Targeted Expression of BRAFV600E in Thyroid Cells of Transgenic Mice Results in Papillary Thyroid Cancers that Undergo Dedifferentiation
JA Knauf, X Ma, EP Smith, L Zhang, N Mitsutake… - Cancer research, 2005 - AACR
The BRAFT1799A mutation is the most common genetic alteration in papillary thyroid
carcinomas (PTC). It is also found in a subset of papillary microcarcinomas, consistent with a …
carcinomas (PTC). It is also found in a subset of papillary microcarcinomas, consistent with a …
Mutationally Activated BRAFV600E Elicits Papillary Thyroid Cancer in the Adult Mouse
Mutated BRAF is detected in approximately 45% of papillary thyroid carcinomas (PTC). To
model PTC, we bred mice with adult-onset, thyrocyte-specific expression of BRAFV600E …
model PTC, we bred mice with adult-onset, thyrocyte-specific expression of BRAFV600E …
Conditional BRAFV600E Expression Induces DNA Synthesis, Apoptosis, Dedifferentiation, and Chromosomal Instability in Thyroid PCCL3 Cells
N Mitsutake, JA Knauf, S Mitsutake, C Mesa Jr, L Zhang… - Cancer research, 2005 - AACR
The activating mutation BRAF T1796A is the most prevalent genetic alteration in papillary
thyroid carcinomas (PTC). It is associated with advanced PTCs, suggesting that this …
thyroid carcinomas (PTC). It is associated with advanced PTCs, suggesting that this …
BRAF V600E maintains proliferation, transformation, and tumorigenicity of BRAF-mutant papillary thyroid cancer cells
D Liu, Z Liu, S Condouris, M Xing - The Journal of Clinical …, 2007 - academic.oup.com
Abstract Context: Although the BRAF V600E mutant can initiate the formation of papillary
thyroid cancer (PTC), it is unclear whether it is required to maintain cell proliferation …
thyroid cancer (PTC), it is unclear whether it is required to maintain cell proliferation …
Immunohistochemical Detection of Mutated BRAF V600E Supports the Clonal Origin of BRAF-Induced Thyroid Cancers Along the Spectrum of Disease Progression
RA Ghossein, N Katabi, JA Fagin - The Journal of Clinical …, 2013 - academic.oup.com
Background: The mutated BRAF V600E protein has been specifically detected in papillary
thyroid carcinomas (PTCs) using immunohistochemical (IHC) analysis. The clonal origin of …
thyroid carcinomas (PTCs) using immunohistochemical (IHC) analysis. The clonal origin of …
BRAFV600E Promotes Invasiveness of Thyroid Cancer Cells through Nuclear Factor κB Activation
I Palona, H Namba, N Mitsutake, D Starenki… - …, 2006 - academic.oup.com
The BRAF V600E mutation is closely linked to tumorigenesis and malignant phenotype of
papillary thyroid cancer. Signaling pathways activated by BRAFV600E are still unclear …
papillary thyroid cancer. Signaling pathways activated by BRAFV600E are still unclear …
High-Sensitivity BRAF Mutation Analysis: BRAF V600E Is Acquired Early During Tumor Development but Is Heterogeneously Distributed in a Subset of Papillary …
D de Biase, V Cesari, M Visani… - The Journal of …, 2014 - academic.oup.com
Context: The homogeneous distribution of BRAF V600E in papillary thyroid carcinoma (PTC)
has been called into question by recent reports. These studies claim that BRAF V600E is …
has been called into question by recent reports. These studies claim that BRAF V600E is …
BRAF mutation in papillary thyroid carcinoma: pathogenic role and clinical implications
KT Tang, CH Lee - Journal of the chinese medical association, 2010 - journals.lww.com
Papillary thyroid cancer (PTC) is the most common endocrine malignancy, accounting for 85–
90% of all thyroid cancers. Genetic alternations involving the mitogen-activated protein …
90% of all thyroid cancers. Genetic alternations involving the mitogen-activated protein …
Thyrotrophin receptor signaling dependence of Braf-induced thyroid tumor initiation in mice
AT Franco, R Malaguarnera… - Proceedings of the …, 2011 - National Acad Sciences
Mutations of BRAF are found in∼ 45% of papillary thyroid cancers and are enriched in
tumors with more aggressive properties. We developed mice with a thyroid-specific knock-in …
tumors with more aggressive properties. We developed mice with a thyroid-specific knock-in …
BRAFV599E Mutation Is the Leading Genetic Event in Adult Sporadic Papillary Thyroid Carcinomas
E Puxeddu, S Moretti, R Elisei, C Romei… - The Journal of …, 2004 - academic.oup.com
Activating mutations of BRAF have been identified in a variety of human cancers, most
notably melanomas and papillary thyroid carcinomas (PTCs). The aim of the present study …
notably melanomas and papillary thyroid carcinomas (PTCs). The aim of the present study …
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