Methods: We constructed a rat model of myocardial injury and compared among 4 groups
(n= 10, each): the sham-operated group (Sham), the ischemia-reperfusion group (IR), the …

Diabetic cardiomyopathy (DCM) is part of the most important causes of death from
cardiovascular disease. Perillaldehyde (PAE), a major component of the herb perilla, has …

Metformin has been shown to protect myocardial ischaemia/reperfusion or
hypoxia/reoxygenation injury. In our current study, we investigated the effects of metformin …

Pathological cardiac hypertrophy often precedes heart failure due to various stimuli, yet
effective clinical interventions remain limited. Recently, microRNAs (miRNAs) have been …

Ghrelin, a novel gut hormone, has been shown to exert protective effects on cardiac
dysfunction and remodeling. However, the underlying mechanisms of its protective effects …

Background Many studies have shown effective protection from myocardial ischemia–
reperfusion injury (MIRI) in animal models, but few, if any, treatments have yielded a …

QiShenYiQi pill (QSYQ), a traditional Chinese medicine, is well known for improving the
myocardial remodelling, but the dose‐effect relationship of its intervention in the reparative …

Abstract Sacubitril/valsartan (SAC/VAL), an angiotensin receptor blocker-neprilysin inhibitor,
has been widely used to treat several types of heart failure. Nevertheless, the effects of …

Heart failure with preserved ejection fraction (HFpEF) is a complex clinical syndrome with
cardiac dysfunction, fluid retention and reduced exercise tolerance as the main …

QiShenYiQi pill (QSYQ), a traditional Chinese medicine, is used to treat cardiovascular
diseases. However, the dose-effect relationship of its intervention in the reactive myocardial …