Most mammalian tissues are organized into a hierarchical structure of stem, progenitor, and
differentiated cells. Tumors exhibit similar hierarchy, even if it is abnormal in comparison …

Hierarchical organized tissue structures, with stem cell driven cell differentiation, are critical
to the homeostatic maintenance of most tissues, and this underlying cellular architecture is …

Most adult tissues consist of stem cells, progenitors, and mature cells, and this hierarchical
architecture may play an important role in the multistep process of carcinogenesis. Here, we …

Abstract Purpose of Review To maintain and repair adult tissues, a balance must be
maintained between stem cell proliferation and generation of differentiated offspring. This …

Tissues are maintained by adult stem cells that self-renew and also differentiate into
functioning tissue cells. Homeostasis is achieved by a set of complex mechanisms that …

Tumor emergence and progression is a complex phenomenon that assumes special
molecular and cellular interactions. The hierarchical structuring and communication via …

Simple Summary Cancer stem cell (CSC) directed therapies have been increasingly
developed during the last years. However, some reported experiments using this strategy …

Tumorigenesis can be seen as an evolutionary process, in which the transformation of a
normal cell into a tumor cell involves a number of limiting genetic and epigenetic events …

Tumors are appreciated to be an intrinsically heterogeneous population of cells with varying
proliferation capacities and tumorigenic potentials. As a central tenet of the so-called cancer …

The cancer stem cell hypothesis has evolved into one of the most important paradigms in
cancer research. According to cancer stem cell hypothesis, somatic mutations in a …