Multisensory gamma stimulation promotes glymphatic clearance of amyloid

MH Murdock, CY Yang, N Sun, PC Pao… - Nature, 2024 - nature.com
The glymphatic movement of fluid through the brain removes metabolic waste,,–.
Noninvasive 40 Hz stimulation promotes 40 Hz neural activity in multiple brain regions and …

Neuronal dynamics direct cerebrospinal fluid perfusion and brain clearance

LF Jiang-Xie, A Drieu, K Bhasiin, D Quintero, I Smirnov… - Nature, 2024 - nature.com
The accumulation of metabolic waste is a leading cause of numerous neurological
disorders, yet we still have only limited knowledge of how the brain performs self-cleansing …

Functional aspects of meningeal lymphatics in ageing and Alzheimer's disease

S Da Mesquita, A Louveau, A Vaccari, I Smirnov… - Nature, 2018 - nature.com
Ageing is a major risk factor for many neurological pathologies, but its mechanisms remain
unclear. Unlike other tissues, the parenchyma of the central nervous system (CNS) lacks …

Gamma frequency entrainment attenuates amyloid load and modifies microglia

HF Iaccarino, AC Singer, AJ Martorell, A Rudenko… - Nature, 2016 - nature.com
Abstract Changes in gamma oscillations (20–50 Hz) have been observed in several
neurological disorders. However, the relationship between gamma oscillations and cellular …

Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy

S Da Mesquita, Z Papadopoulos, T Dykstra, L Brase… - Nature, 2021 - nature.com
Alzheimer's disease (AD) is the most prevalent cause of dementia. Although there is no
effective treatment for AD, passive immunotherapy with monoclonal antibodies against …

A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β

JJ Iliff, M Wang, Y Liao, BA Plogg, W Peng… - Science translational …, 2012 - science.org
Because it lacks a lymphatic circulation, the brain must clear extracellular proteins by an
alternative mechanism. The cerebrospinal fluid (CSF) functions as a sink for brain …

Sleep facilitates clearance of metabolites from the brain: glymphatic function in aging and neurodegenerative diseases

AR Mendelsohn, JW Larrick - Rejuvenation research, 2013 - liebertpub.com
Decline of cognition and increasing risk of neurodegenerative diseases are major problems
associated with aging in humans. Of particular importance is how the brain removes …

Identification of direct connections between the dura and the brain

LCD Smyth, D Xu, SV Okar, T Dykstra, J Rustenhoven… - Nature, 2024 - nature.com
The arachnoid barrier delineates the border between the central nervous system and dura
mater. Although the arachnoid barrier creates a partition, communication between the …

Circadian control of brain glymphatic and lymphatic fluid flow

LM Hablitz, V Plá, M Giannetto, HS Vinitsky… - Nature …, 2020 - nature.com
The glymphatic system is a network of perivascular spaces that promotes movement of
cerebrospinal fluid (CSF) into the brain and clearance of metabolic waste. This fluid …

[HTML][HTML] Spatial transcriptomics reveal neuron–astrocyte synergy in long-term memory

W Sun, Z Liu, X Jiang, MB Chen, H Dong, J Liu… - Nature, 2024 - nature.com
Memory encodes past experiences, thereby enabling future plans. The basolateral
amygdala is a centre of salience networks that underlie emotional experiences and thus has …