Multisensory gamma stimulation promotes glymphatic clearance of amyloid
The glymphatic movement of fluid through the brain removes metabolic waste,,–.
Noninvasive 40 Hz stimulation promotes 40 Hz neural activity in multiple brain regions and …
Noninvasive 40 Hz stimulation promotes 40 Hz neural activity in multiple brain regions and …
Neuronal dynamics direct cerebrospinal fluid perfusion and brain clearance
LF Jiang-Xie, A Drieu, K Bhasiin, D Quintero, I Smirnov… - Nature, 2024 - nature.com
The accumulation of metabolic waste is a leading cause of numerous neurological
disorders, yet we still have only limited knowledge of how the brain performs self-cleansing …
disorders, yet we still have only limited knowledge of how the brain performs self-cleansing …
Functional aspects of meningeal lymphatics in ageing and Alzheimer's disease
Ageing is a major risk factor for many neurological pathologies, but its mechanisms remain
unclear. Unlike other tissues, the parenchyma of the central nervous system (CNS) lacks …
unclear. Unlike other tissues, the parenchyma of the central nervous system (CNS) lacks …
Gamma frequency entrainment attenuates amyloid load and modifies microglia
Abstract Changes in gamma oscillations (20–50 Hz) have been observed in several
neurological disorders. However, the relationship between gamma oscillations and cellular …
neurological disorders. However, the relationship between gamma oscillations and cellular …
Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy
Alzheimer's disease (AD) is the most prevalent cause of dementia. Although there is no
effective treatment for AD, passive immunotherapy with monoclonal antibodies against …
effective treatment for AD, passive immunotherapy with monoclonal antibodies against …
A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β
JJ Iliff, M Wang, Y Liao, BA Plogg, W Peng… - Science translational …, 2012 - science.org
Because it lacks a lymphatic circulation, the brain must clear extracellular proteins by an
alternative mechanism. The cerebrospinal fluid (CSF) functions as a sink for brain …
alternative mechanism. The cerebrospinal fluid (CSF) functions as a sink for brain …
Sleep facilitates clearance of metabolites from the brain: glymphatic function in aging and neurodegenerative diseases
AR Mendelsohn, JW Larrick - Rejuvenation research, 2013 - liebertpub.com
Decline of cognition and increasing risk of neurodegenerative diseases are major problems
associated with aging in humans. Of particular importance is how the brain removes …
associated with aging in humans. Of particular importance is how the brain removes …
Identification of direct connections between the dura and the brain
The arachnoid barrier delineates the border between the central nervous system and dura
mater. Although the arachnoid barrier creates a partition, communication between the …
mater. Although the arachnoid barrier creates a partition, communication between the …
Circadian control of brain glymphatic and lymphatic fluid flow
LM Hablitz, V Plá, M Giannetto, HS Vinitsky… - Nature …, 2020 - nature.com
The glymphatic system is a network of perivascular spaces that promotes movement of
cerebrospinal fluid (CSF) into the brain and clearance of metabolic waste. This fluid …
cerebrospinal fluid (CSF) into the brain and clearance of metabolic waste. This fluid …
[HTML][HTML] Spatial transcriptomics reveal neuron–astrocyte synergy in long-term memory
Memory encodes past experiences, thereby enabling future plans. The basolateral
amygdala is a centre of salience networks that underlie emotional experiences and thus has …
amygdala is a centre of salience networks that underlie emotional experiences and thus has …