Rationale Allopregnanolone effects on mood in postmenopausal women are unclear thus
far. Objectives Allopregnanolone is a neuroactive steroid with contradictory effects …

Objective: To compare severity of negative mood and physical symptoms between women
with different progesterone, allopregnanolone, and pregnanolone plasma concentrations …

The neuroactive steroid 3α-5α-tetrahydroprogesterone (allopregnanolone), a metabolite of
progesterone, is a positive allosteric modulator of GABA A receptors, and low levels have …

Allopregnanolone is a neuroactive metabolite of progesterone and a barbiturate-like
modulator of central γ-aminobutyric acid A receptors that modify a range of behaviors …

Objectives: This observational, cross-sectional study included 140 women with climacteric
symptoms. The aim of the study was to evaluate the correlation between the presence and …

Background: This study was designed to examine basal and stress-induced levels of the
neuroactive progesterone metabolite, allopregnanolone, in women with premenstrual …

Abstract Background: Allopregnanolone (3α-hydroxy-5α-pregnan-20-one) is a neurosteroid
which has an inhibitory function through interaction with the GABAA receptor. This …

Certain women experience negative mood symptoms as a result of progesterone during the
luteal phase of the menstrual cycle, progestagens in hormonal contraceptives, or the …

OBJECTIVE: To evaluate the anxiolytic 3α-5α-reduced progesterone metabolite
allopregnanolone in the luteal phase of the menstrual cycle in women with premenstrual …

Context Allopregnanolone is a metabolite from progesterone and a positive modulator of the
GABA A receptor. This endogenous steroid may induce negative mood in sensitive women …