OBJECTIVE Freshly isolated pancreatic islets contain, in contrast to cultured islets, intraislet
endothelial cells (ECs), which can contribute to the formation of functional blood vessels …

Aims/hypothesis Recent studies suggest that donor endothelial cells may contribute to islet
graft revascularisation. Since islet endothelial cells disappear during culture, we …

Pancreatic islet transplantation is an emerging therapy for type 1 diabetes. To survive and
function, transplanted islets must revascularize because islet isolation severs arterial and …

Pancreatic islet transplantation has emerged as a therapy for type 1 diabetes and is today
performed using both freshly isolated and cultured islets. Islet blood vessels are disrupted …

Islet transplantation has become a widely accepted therapeutic option for selected patients
with type 1 diabetes mellitus. However, in order to achieve insulin independence a great …

An adequate revascularization is crucial for islet survival and function after transplantation.
Previous studies have suggested that islet revascularization is concluded within 14 days …

Although pancreatic islets comprise only 1–2% of pancreatic mass, they receive 5–10% of
pancreatic blood flow. Blood vessels within pancreatic islets are of a greater density than …

Experimental studies indicate low revascularization of intraportally transplanted islets. This
study aimed to quantify, for the first time, the blood perfusion of intrahepatically transplanted …

Impaired revascularization of transplanted islets is a critical problem that leads to
progressive islet loss. Since endothelial progenitor cells (EPCs) are known to aid …

Abstract Background/Aims: An important reason for the large amount of islets required for
successful islet transplantation is likely to be inadequate engraftment of the transplanted …