In allogenic islet transplantation (IT), high purity of islet preparations and low contamination
by nonislet cells are generally favored. The aim of the present study was to analyze the …

Background Islet transplantation is a commonly therapeutic strategy for diabetes mellitus.
However, avascular phase and the poor formation of blood vessels in the late period lead to …

Background. We investigated the influence of exocrine tissue contamination on the process
of vascularization of isolated pancreatic islets of Langerhans after free transplantation into …

Pancreatic islet transplantation into the liver provides a possibility to treat selected patients
with brittle type 1 diabetes mellitus. However, massive early β-cell death increases the …

Transplantation of islets into the portal vein of diabetic patients has emerged as a promising
procedure for the treatment of type 1 diabetes. However, shortages of donors and adverse …

Objective: Although pancreatic islet transplantation can now be performed minimally
invasively in patients with type 1 diabetes, the availability of functional islet donors remains …

Diabetes mellitus results from the anatomical or functional loss of insulin‐producing beta
cells of the pancreas. Despite significant advances in current treatment, patients with …

The intra-islet microvasculature is a critical interface between the blood and islet endocrine
cells governing a number of cellular and pathophysiological processes associated with the …

AIM: To determine whether the elevated vascular endothelial growth factor (VEGF)
expression produced by the transfected vascular endothelial cells (VECs) could stimulate …

Within the pancreatic islet, the β-cell represents the ultimate biosensor. Its central function is
to accurately sense glucose levels in the blood and consequently release appropriate …