Mimicking the human physiology with microphysiological systems (MPS)

JH Sung, J Koo, ML Shuler - BioChip Journal, 2019 - Springer
Microphysiological systems (MPS), also known as organ-on-a-chip technology, combine cell
culture models and microtechnology to mimic tissue microenvironment and provide …

Strategies for using mathematical modeling approaches to design and interpret multi-organ microphysiological systems (MPS)

JH Sung, Y Wang, ML Shuler - APL bioengineering, 2019 - pubs.aip.org
Recent advances in organ-on-a-chip technology have resulted in numerous examples of
microscale systems that faithfully mimic the physiology and pathology of human organs and …

Microphysiological systems to advance human pathophysiology and translational medicine

AD Harriot, CW Ward, DH Kim - Journal of Applied …, 2024 - journals.physiology.org
Microphysiological systems (MPS) or “organ-on-a-chip” models are sophisticated tools that
harness techniques from cell biology, tissue engineering, and microengineering to …

Microfluidic organ-on-a-chip system for disease modeling and drug development

Z Li, J Hui, P Yang, H Mao - Biosensors, 2022 - mdpi.com
An organ-on-a-chip is a device that combines micro-manufacturing and tissue engineering
to replicate the critical physiological environment and functions of the human organs …

Advances in organ-, body-, and disease-on-a-chip systems

ML Shuler - Lab on a Chip, 2019 - pubs.rsc.org
In mid-2017 I wrote an editorial in Lab on a Chip requesting articles for a thematic collection
of papers for a virtual issue on the emergence and advancement of organ-, body-, and …

Pharmacokinetic-based multi-organ chip for recapitulating organ interactions

JH Sung - Methods in Cell Biology, 2018 - Elsevier
Organ-on-a-chip technology provides a novel in vitro platform with a possibility of
reproducing physiological functions of in vivo tissue, more accurately than conventional cell …

Microfluidic-based multi-organ platforms for drug discovery

A Rezaei Kolahchi, N Khadem Mohtaram… - Micromachines, 2016 - mdpi.com
Development of predictive multi-organ models before implementing costly clinical trials is
central for screening the toxicity, efficacy, and side effects of new therapeutic agents. Despite …

Integrated microphysiological systems: Transferable organ models and recirculating flow

K Renggli, N Rousset, C Lohasz… - Advanced …, 2019 - Wiley Online Library
Studying and understanding of tissue and disease mechanisms largely depend on the
availability of suitable and representative biological model systems. These model systems …

Microphysiological systems (tissue chips) and their utility for rare disease research

LA Low, DA Tagle - Rare Diseases Epidemiology: Update and Overview, 2017 - Springer
The scientific and technological development of microphysiological systems (MPS)
modeling organs-on-chips, or “tissue chips”(TCs), has progressed rapidly over the past …

Integrated biosensors for monitoring microphysiological systems

L Mou, K Mandal, MM Mecwan, AL Hernandez… - Lab on a Chip, 2022 - pubs.rsc.org
Microphysiological systems (MPSs), also known as organ-on-a-chip models, aim to
recapitulate the functional components of human tissues or organs in vitro. Over the last …