There is a paucity of data on the role of microglia and neuroinflammatory processes in the
association between chronic pain and depression. The current study examined the effect of …

Substantial evidence indicates involvement of microglia/macrophages in chronic
neuropathic pain. However, the temporal-spatial features of microglial/macrophage …

Glia, particularly astrocytes and microglia, are known to play an important role in central
sensitization and are strongly implicated in the exaggerated pain states. In the present study …

Activation of p38 mitogen‐activated protein kinase (p38) in spinal microglia is implicated in
spinal nociceptive processing. Minocycline, a tetracycline derivative, displays selective …

Clinical studies examining the potential of anti-inflammatory agents, specifically of
minocycline, as a treatment for depression has shown promising results. However …

It has been demonstrated that spinal microglial activation is involved in formalin-induced
pain and that minocycline, an inhibitor of microglial activation, attenuate behavioral …

Activated glial cells (microglia and astroglia) in the spinal cord play a major role in mediating
enhanced pain states by releasing proinflammatory cytokines and other substances thought …

In neuropathic pain the repeated minocycline treatment inhibited the mRNA and protein
expression of the microglial markers and metalloproteinase-9 (MMP-9). The minocycline …

Background Activation of the peripheral innate immune system stimulates the secretion of
CNS cytokines that modulate the behavioral symptoms of sickness. Excessive production of …

Recent research has shown that microglial cells which are strongly activated in neuropathy
can influence development of allodynia and hyperalgesia. Here we demonstrated that …