Global cerebral ischemia (GCI) commonly occurs in the elderly. Subcortical white matter
lesions and oligodendrocyte (OLG) loss caused by cerebral ischemia have been implicated …

The mechanisms associated with diabetes‑induced neuropathic pain are complex and
poorly understood. In order to understand the involvement of spinal microglia activity in …

In this study, we investigated the effects of minocycline, a putative suppressor of microglial
activation, on systemic lipopolysaccharide (LPS)-induced spinal cord inflammation …

Traumatic spinal cord injury (SCI) results not only in motor impairment but also in chronic
central pain, which can be refractory to conventional treatment approaches. It has been …

Accumulating evidences have suggested that anxiety-like behavior and impairment of
learning and memory are key symptoms of post-traumatic stress disorder (PTSD), and …

Microglia participates in the modulation of pain signaling. The activation of microglia is
suggested to play an important role in affective disorders that are related to a dysfunction of …

Recent understanding of the neuron–glia communication shed light on an important role of
microglia to develop neuropathic pain The analgesic effect of minocycline on neuropathic …

Activation of spinal microglia contributes to aberrant pain responses associated with
neuropathic pain states. Endocannabinoids (ECs) are present in the spinal cord, and inhibit …

The high comorbidity rates of posttraumatic stress disorder and chronic pain have been
widely reported, but the underlying mechanisms remain unclear. Emerging evidence …

Minocycline is a semisynthetic, tetracycline derivative that exerts anti‐inflammatory and
neuroprotective effects unrelated to its anti‐microbial action. We have previously shown that …