CNS inflammation mediated by microglial activation can result in neuronal and glial cell
death in a variety of neurodegenerative and demyelinating diseases. Minocycline, a second …

Studies have been suggested that minocycline can be a potential new agent for the
treatment of depression. In addition, both oxidative stress and energy metabolism present an …

Activation of the prefrontal cortex occurs during acute and chronic pain and models of
experimental hyperalgesia. The present study was carried out to determine possible miRNA …

Microglia can modulate spinal nociceptive transmission. Yet, their role in spinal cord
stimulation (SCS)-induced pain inhibition is unclear. Here, we examined how SCS affects …

Plastic changes that increase nociceptive transmission are observed in several brain
regions under conditions of chronic pain. Synaptic plasticity in the anterior cingulate cortex …

Neuropathic pain is one of the most debilitating pain conditions, yet no therapeutic strategy
has been really effective for its treatment. Hence, a better understanding of its …

We have demonstrated that the activation of p38 mitogen-activated protein kinase (MAPK) in
the spinal microglia played an essential role in the development of morphine antinociceptive …

Minocycline is a broad-spectrum tetracycline antibiotic. A number of preclinical studies have
shown that minocycline exhibits neuroprotective effects in various animal models of …

Alcohol use is a well characterized risk factor for traumatic brain injury (TBI); however,
emerging clinical and experimental research suggests that TBI may also be an independent …

A role of neuropeptides in neuropathic pain development has been implicated; however, the
neuroimmune interactions that are involved in the underlying mechanisms may be more …