Tannin extract from maritime pine bark exhibits anticancer properties by targeting the epigenetic UHRF1/DNMT1 tandem leading to the re-expression of TP73

W Ashraf, T Ahmad, NAR Almalki, M Krifa, L Zaayter… - Food & function, 2022 - pubs.rsc.org
Maritime pine bark is a rich source of polyphenolic compounds and is commonly employed
as a herbal supplement worldwide. This study was designed to check the potential of …

[HTML][HTML] Pinostrobin, a fingerroot compound, regulates miR-181b-5p and induces acute leukemic cell apoptosis

C Norkaew, P Subkorn, C Chatupheeraphat… - Scientific Reports, 2023 - nature.com
Pinostrobin (PN) is the most abundant flavonoid found in fingerroot. Although the anti-
leukemic properties of PN have been reported, its mechanisms are still unclear. MicroRNAs …

[HTML][HTML] Anti-leukemic effect of menthol, a peppermint compound, on induction of apoptosis and autophagy

M Naksawat, C Norkaew, K Charoensedtasin… - PeerJ, 2023 - peerj.com
Background Menthol, a natural compound in peppermint leaves, has several biological
activities, including antioxidant, anti-inflammatory, antiviral, antibacterial and anticancer …

Prospects of tangeretin as a modulator of cancer targets/pathways

W Raza, S Luqman, A Meena - Pharmacological Research, 2020 - Elsevier
To date, cancer is the second leading cause of death worldwide after cardiac arrest. A large
number of synthetic drugs are available for the treatment of different types of cancer; …

[HTML][HTML] Anti-Tumor Effect of Pinus massoniana Bark Proanthocyanidins on Ovarian Cancer through Induction of Cell Apoptosis and Inhibition of Cell Migration

J Liu, J Bai, G Jiang, X Li, J Wang, D Wu, L Owusu… - PloS one, 2015 - journals.plos.org
Pinus massoniana bark proanthocyanidins (PMBPs), an active component isolated from
Pinus massoniana bark, has been reported to possess a wide range of biochemical …

[HTML][HTML] Cytotoxicity and Multi-Enzyme Inhibition of Nepenthes miranda Stem Extract on H838 Human Non-Small Cell Lung Cancer Cells and RPA32, Elastase …

CY Lee, YC Chen, YH Huang, Y Lien, CY Huang - Plants, 2024 - mdpi.com
The carnivorous pitcher plants of the genus Nepenthes have long been known for their
ethnobotanical applications. In this study, we prepared various extracts from the pitcher …

A tangeretin derivative inhibits the growth of human prostate cancer LNCaP cells by epigenetically restoring p21 gene expression and inhibiting cancer stem-like cell …

GJ Wei, YH Chao, YC Tung, TY Wu, ZY Su - The AAPS journal, 2019 - Springer
Prostate cancer ranks the second in incidence and the fifth in mortality cancer in male
globally. Citrus polymethoxyflavonoids (PMFs), such as tangeretin (PMF1), have been found …

Trans‐gnetin H isolated from the seeds of Paeonia species induces autophagy via inhibiting mTORC1 signalling through AMPK activation

C Xia, G Wang, L Chen, H Geng, J Yao, Z Bai… - Cell …, 2023 - Wiley Online Library
Paeonia is a well‐known species of ornamental plants, traditional Chinese medicines, and
emerging oilseed crops. Apart from nutritional unsaturated fatty acids, the seeds of peonies …

[HTML][HTML] Flavonoids from the stems of Millettia pachyloba Drake mediate cytotoxic activity through apoptosis and autophagy in cancer cells

W Yan, J Yang, H Tang, L Xue, K Chen, L Wang… - Journal of Advanced …, 2019 - Elsevier
In this study, systematic separation and subsequent pharmacological activity studies were
carried out to identify cytotoxic natural products from the dried stems of Millettia pachyloba …

[HTML][HTML] Extraction and purification of total flavonoids from pine needles of Cedrus deodara contribute to anti-tumor in vitro

X Shi, D Liu, J Zhang, P Hu, W Shen, B Fan… - … and alternative medicine, 2016 - Springer
Background Cedrus deodara is one of the traditional Chinese medicinal herbs that exhibits
a line of biological activities. The current study extracted the total flavonoids from the pine …