Programmed cell death is an important regulatory event in spermatogenesis. However, the
molecular events governing apoptosis have not been characterized. Using the Leydig cell …

Germ cell apoptosis, which occurs normally during spermatogenesis, increases after
testosterone withdrawal from the testis. The molecular mechanism by which this occurs …

Germ cell apoptosis is very common during various stages of mammalian testicular
development. However, our understanding of the mechanisms underlying male germ cell …

Germ cell degeneration is common in mammalian testes during the developmental as well
as the adult period. To investigate the extent and mechanisms of male germ cell death …

BACKGROUND: Caspases are downstream elements of apoptosis-mediating pathways
initiated by the Fas ligand/Fas receptor system which is supposed to play a central role in …

Apoptosis and its augmentation by androgen withdrawal is an important event in the testis.
In other tissues apoptosis is regulated by genes belonging to the bcl-2 family. However, little …

Germ cell apoptosis in testis is essential for functional spermatogenesis. Recent evidence
suggests that the Fas signaling system is critical for the regulation of testicular germ cell …

Apoptosis occurs in the testis as an important physiological mechanism to limit the number
of germ cells in the seminiferous epithelium. Sertoli cells, which tightly regulate germ cell …

The role of Fas in the apoptosis of testicular germ cells was investigated in BALB/c mice and
Fas-deficient lpr/lpr mice. Spontaneous apoptosis of germ cells was observed in the testes of …

The present study investigates the molecular apoptotic pathway in germ cells following
acute ischemia of the rat testis. Rats were subjected to ischemia-inducing torsion and testes …