Retinol saturase (RetSat) is an oxidoreductase involved in lipid metabolism and the cellular
sensitivity to peroxides. RetSat is highly expressed in metabolic organs like liver and …

Retinol saturase (RetSat) catalyzes the saturation of double bonds of all-trans-retinol
leading to the production of dihydroretinoid metabolites. Beside its role in retinoid …

Adipocyte differentiation is controlled by many transcription factors, but few known
downstream targets of these factors are necessary for adipogenesis. Here we report that …

Retinol saturase (RetSat) is an oxidoreductase that is expressed in metabolically active
tissues and is highly regulated in conditions related to insulin resistance and type 2 …

The enzyme retinol saturase (RetSat) catalyzes the saturation of all-trans-retinol to produce
(R)-all-trans-13, 14-dihydroretinol. As a peroxisome proliferator-activated receptor (PPAR) γ …

The liver integrates multiple metabolic pathways to warrant systemic energy homeostasis.
An excessive lipogenic flux due to chronic dietary stimulation contributes to the development …

Apoptosis and the proper clearance of apoptotic cells play a central role in maintaining
tissue homeostasis. Previous work in our laboratory has shown that when a high number of …

Metabolism of vitamin A, all-trans-retinol, leads to the formation of 11-cis-retinaldehyde, the
visual chromophore, and all-trans-retinoic acid, which is involved in the regulation of gene …

We analyzed the retinoid levels and gene expression in various tissues after wild-type (Wt)
and lecithin: retinol acyltransferase (LRAT−/−) knockout mice were fed a high retinol diet …

In the intestinal mucosa, retinoic acid (RA) is a critical signaling molecule. RA is derived from
dietary vitamin A (retinol) through conversion by aldehyde dehydrogenases (aldh). Reduced …