Neurovascular alignment is a common anatomical feature of organs, but the mechanisms
leading to this arrangement are incompletely understood. Here, we show that vascular …

Pancreatic islets are highly vascularized mini-organs, and vascular endothelial growth factor
(VEGF)-A is a critical factor in the development of islet vascularization. To investigate the …

There is a reciprocal interaction between pancreatic islet cells and vascular endothelial cells
(EC) in which EC-derived signals promote islet cell differentiation and islet development …

Endothelial cells are required to initiate pancreas development from the endoderm. They
also control the function of endocrine islets after birth. Here we investigate in developing …

Blood vessels form a highly branched, interconnected, and largely stereotyped network of
tubes that sustains every organ and tissue in vertebrates. How vessels come to take on their …

The vertebrate pancreas is comprised of a highly branched tubular epithelium, which is
intimately associated with an extensive and specialized vasculature. While we know a great …

Blood vessels course through organs, providing them with essential nutrient and gaseous
exchange. However, the vasculature has also been shown to provide non-nutritional signals …

How organ size and form are controlled during development is a major question in biology.
Blood vessels have been shown to be essential for early development of the liver and …

The mechanisms underlying zebrafish pancreatic islet vascularization have not been well
characterized. We sought to determine the angiogenic factors responsible for islet …

An important question is how growing tissues establish a blood vessel network. Here we
study vascular network formation in pancreatic islets, endocrine tissues derived from …