Macrophages have specialized functions in different tissue microenvironments such as
lymphohaemopoietic organs and the nervous system. Recently, progress has been made in …

Macrophages display remarkable plasticity and can change their physiology in response to
environmental cues. These changes can give rise to different populations of cells with …

Studies in the last 20 years have given us a remarkable insight into the functional and
phenotypic diversity of macrophages which reflects their integral role in host defence …

Macrophages are cells of the innate immunity constituting the mononuclear phagocyte
system and endowed with remarkable different roles essential for defense mechanisms …

Monocytes are circulating blood leukocytes that play important roles in the inflammatory
response, which is essential for the innate response to pathogens. But inflammation and …

Tissue macrophages are resident phagocytes that acquire specific phenotypes according to
the microenvironment. Morphological and functional heterogeneity has been evidenced in …

Novel experimental approaches such as fate-mapping and single-cell analysis have brought
fresh insight into monocyte development and function over the past decade and helped …

The mononuclear phagocyte system (MPS) has historically been categorized into
monocytes, dendritic cells and macrophages on the basis of functional and phenotypical …

Macrophages are essential for the efficient healing of numerous tissues, and they contribute
to impaired healing and fibrosis. Tissue repair proceeds through overlapping phases of …

Current macrophage phenotype classifications are based on distinct in vitro culture
conditions that do not adequately mirror complex tissue environments. In vivo monocyte …