[HTML][HTML] Genetic and epigenetic instability induced by betel quid associated chemicals

RB Muthukumaran, P Bhattacharjee, P Bhowmick… - Toxicology reports, 2023 - Elsevier
Over the years, betel quid chewing and tobacco use have attracted considerable interest as
they are implicated as the most likely causative risk factors of oral and esophageal cancers …

Areca nut extract up-regulates prostaglandin production, cyclooxygenase-2 mRNA and protein expression of human oral keratinocytes

JH Jeng, YS Ho, CP Chan, YJ Wang, LJ Hahn… - …, 2000 - academic.oup.com
There are about 600 million betel quid (BQ) chewers in the world. BQ chewing is associated
with increased incidence of oral cancer and submucous fibrosis. In this study, areca nut (AN) …

Bitter Melon Prevents the Development of 4-NQO–Induced Oral Squamous Cell Carcinoma in an Immunocompetent Mouse Model by Modulating Immune Signaling

S Sur, R Steele, R Aurora, M Varvares… - Cancer Prevention …, 2018 - AACR
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer
worldwide, and tobacco is one of the most common factors for HNSCC of the oral cavity. We …

[Retracted] Chemical Composition, Pharmacological, and Toxicological Effects of Betel Nut

X Chen, Y He, Y Deng - Evidence‐Based Complementary and …, 2021 - Wiley Online Library
Betel nut, the fruit of Areca catechu L, has a long medical history in Southeast Asia. It is
native to Malaysia and is cultivated and processed extensively in subtropical regions, such …

Molecular mechanisms of malignant transformation of oral submucous fibrosis by different betel quid constituents—does fibroblast senescence play a role?

P Zhang, NQE Chua, S Dang, A Davis… - International Journal of …, 2022 - mdpi.com
Betel quid (BQ) is a package of mixed constituents that is chewed by more than 600 million
people worldwide, particularly in Asia. The formulation of BQ depends on a variety of factors …

Tobacco (kretek) smoking, betel quid chewing and risk of oral cancer in a selected Jakarta population

R Amtha, IA Razak, B Basuki, BO Roeslan… - Asian Pacific Journal …, 2014 - koreascience.kr
Purpose: This study aimed to determine the association between tobacco consumption
(kretek) and betel quid chewing with oral cancer risk. Materials and Methods: A total of 81 …

The magnitude of tobacco smoking-betel quid chewing-alcohol drinking interaction effect on oral cancer in South-East Asia. A meta-analysis of observational studies

S Petti, M Masood, C Scully - PloS one, 2013 - journals.plos.org
Tobacco smoking, betel quid chewing and alcohol drinking are oral cancer risk factors.
Observational studies unanimously report that oral cancer risk in smoking-drinking-chewing …

Effects of pH on nicotine-induced DNA damage and oxidative stress

HJ Wu, CW Chi, TY Liu - Journal of Toxicology and Environmental …, 2005 - Taylor & Francis
Epidemiological evidence suggests that chewing betel quid and smoking have synergistic
potential in the development of oral squamous-cell carcinoma in Taiwan. Chewing betel …

Arecoline, a major alkaloid of areca nut, inhibits p53, represses DNA repair, and triggers DNA damage response in human epithelial cells

YS Tsai, KW Lee, JL Huang, YS Liu, SHH Juo, WR Kuo… - Toxicology, 2008 - Elsevier
The International Agency for Research on Cancer declared that areca nut was carcinogenic
to human. Areca nut is the main component of betel quid (BQ), which is commonly …

Pilot study of the pharmacokinetics of betel nut and betel quid biomarkers in saliva, urine, and hair of betel consumers

AA Franke, X Li, JF Lai - Drug testing and analysis, 2016 - Wiley Online Library
Approximately 600 million people worldwide practise the carcinogenic habit of betel nut/quid
chewing. Carcinogenic N‐nitroso compounds have been identified in saliva or urine of betel …