Developing neuroprotective strategies for treatment of HIV-associated neurocognitive dysfunction

JA Rumbaugh, J Steiner, N Sacktor, A Nath - Future HIV therapy, 2008 - Taylor & Francis
Important advances have been made in recent years in identifying the molecular
mechanisms of HIV neuropathogenesis. Defining the pathways leading to HIV dementia has …

Developments in HIV neuropathogenesis

JA Rumbaugh, A Nath - Current pharmaceutical design, 2006 - ingentaconnect.com
Despite the fact that neurons are rarely infected by the human immunodeficiency virus (HIV),
neuronal loss is common in patients with HIV infection, likely due to the effects of viral …

HIV-associated neurocognitive disorder: pathogenesis and therapeutic opportunities

KA Lindl, DR Marks, DL Kolson… - Journal of neuroimmune …, 2010 - Springer
Human immunodeficiency virus type 1 (HIV) infection presently affects more that 40 million
people worldwide, and is associated with central nervous system (CNS) disruption in at least …

Mechanisms underlying HIV-associated cognitive impairment and emerging therapies for its management

RJ Ellis, MJ Marquine, M Kaul, JA Fields… - Nature Reviews …, 2023 - nature.com
People living with HIV are affected by the chronic consequences of neurocognitive
impairment (NCI) despite antiretroviral therapies that suppress viral replication, improve …

Neuropathogenesis of HIV and emerging therapeutic targets

A Siddiqui, C He, G Lee, A Figueroa… - Expert opinion on …, 2022 - Taylor & Francis
Introduction HIV infection causes a wide range of neurological complications, many of which
are among the most common complications of chronic HIV infection in the era of combined …

Mechanisms of neuroimmunity and neurodegeneration associated with HIV-1 infection and AIDS

M Kaul, SA Lipton - Journal of Neuroimmune Pharmacology, 2006 - Springer
Infection with the human immunodeficiency virus-1 (HIV-1) and acquired immunodeficiency
syndrome (AIDS) are a persistent health problem worldwide. HIV-1 seems to enter the brain …

Mechanisms of neuronal injury and death in HIV-1 associated dementia

M Kaul, SA Lipton - Current HIV research, 2006 - ingentaconnect.com
Infection with the human immunodeficiency virus-1 (HIV-1) and acquired immunodeficiency
syndrome (AIDS) remain a persistent and even growing health problem worldwide. Besides …

HIV-associated neurotoxicity and cognitive decline: Therapeutic implications

DR Wallace - Pharmacology & Therapeutics, 2022 - Elsevier
As our understanding of changes to the neurological system has improved, it has become
clear that patients who have contracted human immunodeficiency virus type 1 (HIV-1) can …

Neurobiology of HIV

B Hult, G Chana, E Masliah, I Everall - International Review of …, 2008 - Taylor & Francis
The importance of HIV cognitive impairment, including HIV associated dementia (HAD) and
minor cognitive/motor disorder, has continued in the era of highly active antiretroviral …

Neuroprotective therapy for HIV dementia

J Turchan, N Sacktor, V Wojna, K Conant… - Current HIV …, 2003 - ingentaconnect.com
Despite the development and use of effective antiretroviral therapy, HIV dementia persists
and has important socio-economic consequences. Significant progress has been made in …