Glucose tolerance and insulin sensitivity are impaired in APP/PS1 transgenic mice prior to amyloid plaque pathogenesis and cognitive decline

L Macklin, CM Griffith, Y Cai, GM Rose, XX Yan… - Experimental …, 2017 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by beta-
amyloid (Aβ) deposition, neurofibrillary tangles and cognitive decline. Clinical data suggests …

Ethanol withdrawal is required to produce persisting N-methyl-D-aspartate receptor-dependent hippocampal cytotoxicity during chronic intermittent ethanol exposure

AR Reynolds, JN Berry, L Sharrett-Field… - Alcohol, 2015 - Elsevier
Chronic intermittent ethanol consumption is associated with neurodegeneration and
cognitive deficits in preclinical laboratory animals and in the clinical population. While …

Prenatal alcohol exposure causes persistent microglial activation and age-and sex-specific effects on cognition and metabolic outcomes in an Alzheimer's Disease …

KR Walter, DK Ricketts, BH Presswood… - The American journal …, 2023 - Taylor & Francis
Background: Prenatal alcohol exposure (PAE) causes behavioral deficits and increases risk
of metabolic diseases. Alzheimer's Disease (AD) is a neurodegenerative disease that has a …

Ethanol tolerance affects endogenous adenosine signaling in mouse hippocampus

D Zhang, W Xiong, MF Jackson, FE Parkinson - Journal of Pharmacology …, 2016 - ASPET
Ethanol has many pharmacological effects, including increases in endogenous adenosine
levels and adenosine receptor activity in brain. Ethanol consumption is associated with both …

Alzheimer's disease and methanol toxicity (part 2): lessons from four rhesus macaques (Macaca mulatta) chronically fed methanol

M Yang, J Miao, J Rizak, R Zhai… - Journal of …, 2014 - content.iospress.com
A recently established link between formaldehyde, a methanol metabolite, and Alzheimer's
disease (AD) pathology has provided a new impetus to investigate the chronic effects of …

Aerobic Exercise Combined with Antioxidative Treatment does not Counteract Moderate‐or Mid‐Stage A lzheimer‐Like Pathophysiology of APP/PS 1 Mice

ZQ Xu, LQ Zhang, Q Wang, C Marshall… - CNS neuroscience & …, 2013 - Wiley Online Library
Aims The present study evaluated the combined treatment effects of aerobic exercise and
antioxidative stress on moderate‐stage A lzheimer's disease (AD). Methods Ten‐month‐old …

Effects of short‐term Western diet on cerebral oxidative stress and diabetes related factors in APP× PS1 knock‐in mice

CM Studzinski, F Li, AJ Bruce‐Keller… - Journal of …, 2009 - Wiley Online Library
A chronic high fat Western diet (WD) promotes a variety of morbidity factors although
experimental evidence for short‐term WD mediating brain dysfunction remains to be …

Effects of chronic and binge ethanol administration on mouse cerebellar and hippocampal neuroinflammation

VM Niedzwiedz-Massey, JC Douglas… - The American journal …, 2023 - Taylor & Francis
Background: Hippocampal and cerebellar neuropathology occurs in individuals with alcohol
use disorders (AUD), resulting in impaired cognitive and motor function. Objectives …

Moderate ethanol preconditioning of rat brain cultures engenders neuroprotection against dementia-inducing neuroinflammatory proteins: possible signaling …

MA Collins, EJ Neafsey, K Wang, NJ Achille… - Molecular …, 2010 - Springer
There is no question that chronic alcohol (ethanol) abuse, a leading worldwide problem,
causes neuronal dysfunction and brain damage. However, various epidemiologic studies in …

[HTML][HTML] Modulation of hepatic amyloid precursor protein and lipoprotein receptor-related protein 1 by chronic alcohol intake: Potential link between liver steatosis and …

J Garcia, R Chang, RA Steinberg, A Arce… - Frontiers in …, 2022 - frontiersin.org
Heavy alcohol consumption is a known risk factor for various forms of dementia and the
development of Alzheimer's disease (AD). In this work, we investigated how intragastric …