Alcoholism is associated with brain damage and impaired cognitive functioning. The relative
contributions of different etiological factors, such as alcohol, thiamine deficiency and age …

Heavy drinking can induce early-onset dementia and increase the likelihood of the
progression and severity of Alzheimer's Disease and related dementias (ADRD). Recently …

Inflammatory processes and cytokine expression have been implicated in the pathogenesis
of several neurodegenerative disorders. Chronic ethanol intake induces brain damage …

The loss of synapses and a corresponding reduction in synaptic proteins are
histopathological features of Alzheimer's disease that correlate strongly with dementia. Here …

To investigate the effects of alcohol intake on cognitive function and β-amyloid protein (Aβ)
in APP/PS1 double-transgenic mice with Alzheimer's disease (AD). Sixty APP/PS1 …

Long-term intake of ethanol produces adaptive alterations in multiple transmitter systems in
the hippocampal formation that likely contribute to ethanol withdrawal-induced seizure and …

Introduction Despite the extensive mechanistic and pathological characterization of the
amyloid precursor protein (APP)/presenilin-1 (PS-1) knock-in mouse model of Alzheimer's …

Although no animal model exactly duplicates clinically defined alcoholism, models for
specific factors, such as the withdrawal syndrome, are useful for identifying potential neural …

Evidence that brain edema and aquaporin-4 (AQP4) water channels have roles in
experimental binge ethanol-induced neurodegeneration has stimulated interest in …

Alterations in the endocannabinoid system (ECS) are thought to play a role in learning and
memory impairments observed in Alzheimer's disease (AD). We aimed to determine the …