Overweight and obesity are major contributors to both type 2 diabetes and cardiovascular
disease (CVD). Moreover, individuals with type 2 diabetes who are overweight or obese are …

Background Weight loss is recommended for overweight or obese patients with type 2
diabetes on the basis of short-term studies, but long-term effects on cardiovascular disease …

OBJECTIVE—The effectiveness of intentional weight loss in reducing cardiovascular
disease (CVD) events in type 2 diabetes is unknown. This report describes 1-year changes …

Abstract The Look AHEAD (Action for Health in Diabetes) study is a multicenter, randomized
controlled trial designed to determine whether intentional weight loss reduces …

OBJECTIVE Short-term weight loss improves cardiovascular disease (CVD) risk factors. We
sought to determine the longer-term effects of maintaining weight loss or, conversely …

OBJECTIVE Overweight and obese individuals are encouraged to lose 5–10% of their body
weight to improve cardiovascular disease (CVD) risk, but data supporting this …

Obesity is a major risk factor for development of diabetes, and excessive energy intake is a
major contributor to poor glycemic control in Type 2 diabetes. The impact of obesity on risk …

Given the array of adverse health consequences of obesity, including increased risk for type
2 diabetes mellitus (T2DM) and cardiovascular disease (CVD), the Look AHEAD trial (N …

Background The obesity epidemic is driving the increased prevalence of type 2 diabetes
mellitus (T2 DM), and the vast majority of patients with T2 DM are overweight or obese …

BACKGROUND: Most persons with type 2 diabetes are overweight, and obesity worsens the
metabolic and physiologic abnormalities associated with diabetes. Our objective was to …