Radiation therapy is a highly effective local treatment for cancer. However, sporadic events
of tumor regression in unirradiated fields, known as abscopal effect, have been observed for …

The abscopal effect is potentially important for tumor control and is mediated through
cytokines and/or the immune system, mainly cell-mediated immunity. It results from loss of …

Background Recently, immunologic responses to localized irradiation are proposed as
mediator of systemic effects after localized radiotherapy (called the abscopal effect). Here …

Mounting evidence suggests that radiation stimulates the immune system and this
contributes to the abscopal effect, which is defined as “response at a distance from the …

Purpose The abscopal effect is defined when a form of local therapy causes tumor
regression of both the target lesion and any untreated tumors. Herein cases of the abscopal …

The concept of utilizing localized radiation therapy to elicit out-of-target tumor responses—
the abscopal effect—was proposed over 50 years ago (1, 2). Over the past decades, the …

The abscopal effect is mediated by a systemic anti-tumor immune response and reflects the
regression of non-irradiated metastatic lesions at a distance from the primary site of …

For over a century, ionising radiation has been used to treat cancer based on its cytotoxic
effects on tumour cells. Technical progress has enabled more precise targeting of the …

An “abscopal” effect occurs when localized irradiation perturbs the organism as a whole,
with consequences that can be either beneficial or detrimental. Mechanistic explanations of …

Radiotherapy has been used for more than a hundred years to cure or locally control tumors.
Regression of tumors outside of the irradiated field was occasionally observed and is known …