Minocycline and other tetracycline derivatives: a neuroprotective strategy in Parkinson's disease and Huntington's disease

M Thomas, WD Le, J Jankovic - Clinical neuropharmacology, 2003 - journals.lww.com
Remarkable progress has been made during the past decade in our understanding of
mechanisms of cell death in neurodegenerative disorders such as Parkinson's disease (PD) …

[HTML][HTML] The therapeutic role of minocycline in Parkinson's disease

S Cankaya, B Cankaya, U Kilic, E Kilic, B Yulug - Drugs in context, 2019 - ncbi.nlm.nih.gov
Minocycline, a semisynthetic tetracycline-derived antibiotic, has been shown to exert anti-
apoptotic, anti-inflammatory, and antioxidant effects. Furthermore, there is rapidly growing …

Minocycline: neuroprotective mechanisms in Parkinson's disease

M Thomas, WD Le - Current pharmaceutical design, 2004 - ingentaconnect.com
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by
cardinal features of tremor, bradykinesia, rigidity and postural instability. In addition to the …

Clinical potential of minocycline for neurodegenerative disorders

D Blum, A Chtarto, L Tenenbaum, J Brotchi… - Neurobiology of …, 2004 - Elsevier
Minocycline, an antibiotic of the tetracycline family, has been shown to display
neurorestorative or neuroprotective properties in various models of neurodegenerative …

Neuroprotective effects of tetracyclines: molecular targets, animal models and human disease

D Orsucci, V Calsolaro, M Mancuso… - CNS & Neurological …, 2009 - ingentaconnect.com
Tetracyclines are a class of antibiotics which could play a therapeutic role in several
neurological disorders. Minocycline, extensively studied in animal models, decreased the …

Tetracyclines and neuromuscular disorders

D Orsucci, M Mancuso, M Filosto… - Current …, 2012 - ingentaconnect.com
Tetracyclines are a class of antibiotics which could act as neuroprotective molecules in
several neurological disorders, such as Huntington disease, Parkinson disease, stroke and …

Tetracycline repurposing in neurodegeneration: focus on Parkinson's disease

M Bortolanza, GC Nascimento, SB Socias… - Journal of neural …, 2018 - Springer
The prevalence of Parkinson's disease, which affects millions of people worldwide, is
increasing due to the aging population. In addition to the classic motor symptoms caused by …

Deleterious effects of minocycline in animal models of Parkinson's disease and Huntington's disease

E Diguet, PO Fernagut, X Wei, Y Du… - European Journal of …, 2004 - Wiley Online Library
Minocycline has been shown to exert anti‐inflammatory effects underlying its putative
neuroprotective properties in the 1‐methyl‐4‐phenyl‐1, 2, 3, 6‐tetrahydropyridine (MPTP) …

The potential of minocycline for neuroprotection in human neurologic disease

D Zemke, A Majid - Clinical neuropharmacology, 2004 - journals.lww.com
Minocycline is a member of the tetracycline class of molecules with broad-spectrum
antibiotic activity. The unique properties of minocycline result in increased tissue distribution …

Minocycline as a neuroprotective agent

DP Stirling, KM Koochesfahani, JD Steeves… - The …, 2005 - journals.sagepub.com
Several studies have shown that minocycline, a semisynthetic, second-generation
tetracycline derivative, is neuroprotective in animal models of central nervous system trauma …