Dopamine agonist-induced dyskinesias are correlated to both firing pattern and frequency alterations of pallidal neurones in the MPTP-treated monkey
Despite the importance and frequency of levodopa-induced dyskinesias, little is known
about their causal mechanisms. In this study, electrophysiological single-unit recordings of …
about their causal mechanisms. In this study, electrophysiological single-unit recordings of …
Levodopa or D2 agonist induced dyskinesia in MPTP monkeys: correlation with changes in dopamine and GABAA, receptors in the striatopallidal complex
Dopamine D1 and D2 receptors as well as the GABA/benzodiazepine receptor complex in
the striatum and the globus pallidus (internal: GPi and external: GPe) were studied by …
the striatum and the globus pallidus (internal: GPi and external: GPe) were studied by …
Effects of dopamine agonists on the spontaneous activity of globus pallidus neurons in monkeys with MPTP-induced parkinsonism
M Filion, JB Paul - Brain research, 1991 - Elsevier
The mixed (D 1 and D 2) dopamine agonist apomorphine was injected (10–200 μg/kg, sc) to
cynomolgus monkeys before and after they were rendered parkinsonian by 1-methyl-4 …
cynomolgus monkeys before and after they were rendered parkinsonian by 1-methyl-4 …
Responses of pallidal neurons to striatal stimulation in monkeys with MPTP-induced parkinsonism
M Filion, JB Paul - Brain research, 1989 - Elsevier
Extracellular single unit activity was recorded from neurons of the internal (GPi) and external
(GPe) pallidal segments, and from 'border cells'(Bor) which are part of the nucleus basalis, in …
(GPe) pallidal segments, and from 'border cells'(Bor) which are part of the nucleus basalis, in …
Switching from levodopa to the long-acting dopamine D2/D3 agonist piribedil reduces the expression of dyskinesia while maintaining effective motor activity in MPTP …
LA Smith, MJ Jackson, L Johnston… - Clinical …, 2006 - journals.lww.com
Background: The control of motor complications following dopaminergic medication in late-
stage Parkinson disease remains problematic. Objective: We now investigate the potential of …
stage Parkinson disease remains problematic. Objective: We now investigate the potential of …
Factors influencing the onset and persistence of dyskinesia in MPTP-treated primates.
P Jenner - Annals of neurology, 2000 - europepmc.org
The 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine treated primate model of Parkinson's
disease provides a unique opportunity to study factors influencing the onset and persistence …
disease provides a unique opportunity to study factors influencing the onset and persistence …
Effects of L-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey
We studied the effects of l-DOPA on the firing patterns of pallidal neurons in experimental
parkinsonism. After a unilateral injection of MPTP, we observed a decrease in the firing rate …
parkinsonism. After a unilateral injection of MPTP, we observed a decrease in the firing rate …
Effect of non-dopaminergic drug treatment on Levodopa induced dyskinesias in MPTP monkeys: common implication of striatal neuropeptides
MK Tamim, P Samadi, M Morissette, L Grégoire… - …, 2010 - Elsevier
Dopamine denervation in Parkinson's disease and repeated Levodopa (L-DOPA)
administration that induces dyskinesias are associated with an enhancement of basal …
administration that induces dyskinesias are associated with an enhancement of basal …
Both short-and long-acting D-1/D-2 dopamine agonists induce less dyskinesia than L-DOPA in the MPTP-lesioned common marmoset (Callithrix jacchus)
EC Maratos, MJ Jackson, RKB Pearce… - Experimental …, 2003 - Elsevier
The current concept of dyskinesia is that pulsatile stimulation of D-1 or D-2 receptors by l-
DOPA or short-acting dopamine agonists is more likely to induce dyskinesia compared to …
DOPA or short-acting dopamine agonists is more likely to induce dyskinesia compared to …
Drug-induced dyskinesia in primates rendered hemiparkinsonian by intracarotid administration of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)
CE Clarke, S Boyce, RG Robertson… - Journal of the …, 1989 - Elsevier
The right common carotid artery was surgically exposed under general anaesthesia in 6
cynomolgus monkeys and MPTP (0.5–2.2 mg/kg) directly infused. This produced a …
cynomolgus monkeys and MPTP (0.5–2.2 mg/kg) directly infused. This produced a …