Anticancer Activity of Silver–N‐Heterocyclic Carbene Complexes: Caspase‐Independent Induction of Apoptosis via Mitochondrial Apoptosis‐Inducing Factor (AIF)
L Eloy, AS Jarrousse, ML Teyssot, A Gautier… - …, 2012 - Wiley Online Library
Fourteen silver (I) complexes bearing N‐heterocyclic carbene (NHC) ligands were prepared
and evaluated for anticancer activity. Some of these were found to exhibit potent …
and evaluated for anticancer activity. Some of these were found to exhibit potent …
Preparation and characterization of amino-linked heterocyclic carbene palladium, gold, and silver complexes and their use as anticancer agents that act by triggering …
CH Wang, WC Shih, HC Chang, YY Kuo… - Journal of Medicinal …, 2011 - ACS Publications
Transition metal complexes bearing amino linked N-heterocyclic carbenes (NHC) were
prepared and evaluated for their antiproliferative activities in human cancer cells. The …
prepared and evaluated for their antiproliferative activities in human cancer cells. The …
Novel fast-acting pyrazole/pyridine-functionalized N-heterocyclic carbene silver complexes assembled with nanoparticles show enhanced safety and efficacy as …
C Chen, L Zhou, B Xie, Y Wang, L Ren, X Chen… - Dalton …, 2020 - pubs.rsc.org
In this study, we designed and synthesized four novel multi-nuclear silver complexes (1–4)
coordinated with pyrazole-or pyridine-functionalized N-heterocyclic carbene (NHC) ligands …
coordinated with pyrazole-or pyridine-functionalized N-heterocyclic carbene (NHC) ligands …
Macrophage and colon tumor cells as targets for a binuclear silver (I) N-heterocyclic carbene complex, an anti-inflammatory and apoptosis mediator
Chronic inflammation intensifies the risk for malignant neoplasm, indicating that curbing
inflammation could be a valid strategy to prevent or cure cancer. Cancer and inflammation …
inflammation could be a valid strategy to prevent or cure cancer. Cancer and inflammation …
Novel gold and silver carbene complexes exert antitumor effects triggering the reactive oxygen species dependent intrinsic apoptotic pathway
D Iacopetta, A Mariconda, C Saturnino… - …, 2017 - Wiley Online Library
Cisplatin and other platinum‐based drugs are well‐known valid anticancer drugs. However,
during chemotherapy, the presence of numerous side effects and the onset of frequent …
during chemotherapy, the presence of numerous side effects and the onset of frequent …
Singly protonated dehydronorcantharidin silver coordination polymer induces apoptosis of lung cancer cells via reactive oxygen species-mediated mitochondrial …
S Li, S Zhang, X Jin, X Tan, J Lou, X Zhang… - European journal of …, 2014 - Elsevier
Silver complexes have been shown to possess antimicrobial and anticancer properties. Ag-
SP-DNC, a novel silver and singly protonated dehydronorcantharidin complex, was …
SP-DNC, a novel silver and singly protonated dehydronorcantharidin complex, was …
Antitumor properties and mechanisms of mitochondria-targeted Ag(i) and Au(i) complexes containing N-heterocyclic carbenes derived from cyclophanes
Metal/N-heterocyclic carbene (NHC) complexes hold great opportunities for the
development of novel antitumor metallodrugs. Herein, four Ag (i) and Au (i) complexes …
development of novel antitumor metallodrugs. Herein, four Ag (i) and Au (i) complexes …
Fluorescent silver(i) and gold(i)–N-heterocyclic carbene complexes with cytotoxic properties: mechanistic insights
A Citta, E Schuh, F Mohr, A Folda, ML Massimino… - Metallomics, 2013 - academic.oup.com
Silver (i) and gold (i)–N-heterocyclic carbene (NHC) complexes bearing a fluorescent
anthracenyl ligand were examined for cytotoxicity in normal and tumor cells. The silver (i) …
anthracenyl ligand were examined for cytotoxicity in normal and tumor cells. The silver (i) …
Preclinical anti-cancer activity and multiple mechanisms of action of a cationic silver complex bearing N-heterocyclic carbene ligands
SJ Allison, M Sadiq, E Baronou, PA Cooper, C Dunnill… - Cancer letters, 2017 - Elsevier
Organometallic complexes offer the prospect of targeting multiple pathways that are
important in cancer biology. Here, the preclinical activity and mechanism (s) of action of a …
important in cancer biology. Here, the preclinical activity and mechanism (s) of action of a …
Human colon cancer targeted pro-apoptotic, anti-metastatic and cytostatic effects of binuclear Silver (I)–N-Heterocyclic carbene (NHC) complexes
The current mechanistic study was conducted to explore the effects of increased lipophilicity
of binuclear silver (I)–NHC complexes on cytotoxicity. Two new silver (I)–N-Heterocyclic …
of binuclear silver (I)–NHC complexes on cytotoxicity. Two new silver (I)–N-Heterocyclic …
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