Not all genetic loci follow Mendel's rules, and the evolutionary consequences of this are not
yet fully known. Genomic conflict involving multiple loci is a likely outcome, as restoration of …

One approach to understanding the process of speciation is to characterize the genetic
architecture of post-zygotic isolation. As gene regulation requires interactions between loci …

Meiotic drive occurs when one allele at a heterozygous site cheats its way into a
disproportionate share of functional gametes, violating Mendel's law of equal segregation …

The t-haplotype, a mouse meiotic driver found on chromosome 17, has been a model for
autosomal segregation distortion for close to a century, but several questions remain …

Regulatory changes in genes involved in reproduction are thought to be prime targets for
divergence during speciation, since they are expected to play an important role in sexual …

Background: DNA methylation (DNAme) and histone posttranslational modifications (PTMs)
play an integral role in the transcriptional regulation of specific sets of genes and …

Abstract The Dobzhansky–Muller (DM) model provides a widely accepted mechanism for
the evolution of reproductive isolation: incompatible substitutions disrupt interactions …

The house mouse hybrid zone (HMHZ) is a species barrier thought to be maintained by a
balance between dispersal and natural selection against hybrids. While the HMHZ is …

Mapping hybrid defects in contact zones between incipient species can identify genomic
regions contributing to reproductive isolation and reveal genetic mechanisms of speciation …

The ability to subvert independent assortment of chromosomes is found in many meiotic
drivers, such as the t haplotype in house mice Mus musculus, in which the t-bearing …