Background Anorexia nervosa is a complex neuropsychiatric disorder presenting with life-
threatening low body weight, and a persistent fear of gaining weight. To date, no whole …

Purpose The aim of this study was to increase knowledge of genes associated with anorexia
nervosa (AN) and their diagnostic offer, using a next generation sequencing (NGS) panel for …

Human genetic studies have associated Neuronatin gene variants with anorexia nervosa
(AN) and obesity. Studies on the expression of the Neuronatin gene product, a proteolipid …

Purpose Increased susceptibility towards anorexia nervosa (AN) was reported with reduced
levels of neuronatin (NNAT) gene. We sought to investigate the most pathogenic rare-coding …

Background Neuronatin (NNAT) is an endoplasmic reticulum proteolipid implicated in
intracellular signalling. Nnat is highly-expressed in the hypothalamus, where it is acutely …

Neuronatin (Nnat) has previously been reported to be part of a network of imprinted genes
downstream of the chromatin regulator Trim28. Disruption of Trim28 or of members of this …

Anorexia nervosa (AN) is a disease defined by inappropriate weight loss and maintenance
of body weight< 85% of that expected for weight and height; it is most common in adolescent …

Noonan syndrome (NS) is a genetic disease inherited in an autosomal dominant mode; it
presents significant genetic heterogeneity and varying penetrance. Mutations have been …

Background Several lines of evidence indicate that the central cannabinoid receptor 1
(CNR1) as well as the major endocannabinoid degrading enzymes fatty acid amide …

Using restriction fragment differential display (RFDD) technology, we have identified the
imprinted gene neuronatin (Nnat) as a hypothalamic target under the influence of leptin …