Objective To assess the effect of abatacept (CTLA‐4Ig), which limits T cell activation, on
homeostasis of CD4+ T cell subsets and T cell–dependent B cell hyperactivity in patients …

Objective. To assess the effect of B cell depletion therapy on effector CD4+ T cell
homeostasis and its relation to objective measures of disease activity in patients with …

Objective To prospectively evaluate histopathologic, blood cellular, serologic, and clinical
changes in response to abatacept treatment in patients with primary Sjögren's syndrome …

Objective. The aim of this study was to assess the histopathological changes in parotid
gland tissue of primary Sjogren's syndrome (pSS) patients treated with abatacept. Methods …

Objective To investigate whether the balance of blood follicular helper T (Tfh) cells and T
follicular regulatory (Tfr) cells can provide information about ectopic lymphoid neogenesis …

Background Immunopathogenesis of rheumatoid arthritis (RA) is not yet clearly defined.
Besides known B-cell involvement, RA development and evolution involves CD4+ T helper …

There is accumulating evidence that patients with primary Sjögren's syndrome (pSS) display
aberrant CD4+ T cell responses, both in the peripheral compartment and in the inflamed …

Abstract Introduction IL-10--producing B cells, Foxp3-expressing T cells (Tregs) and the IDO-
expressing dendritic cells (pDC) are able to modulate inflammatory processes, to induce …

Primary Sjögren's syndrome (pSS) is a chronic autoimmune disease, characterized by
lymphocytic infiltration into exocrine glands, which causes dry eyes, dry mouth, and systemic …

Objective To assess the phenotype of reconstituting B cells after B cell depletion, and to
assess the effect of reconstitution on the balance of Treg cells and effector T cells in patients …