Several animal species are used to study calcium oxalate urolithiasis; however, an ideal
model has yet to be identified. We used Drosophila as a model organism and fed the flies …

Nephrolithiasis is a major public health problem with a complex and varied etiology. Most
stones are composed of calcium oxalate (CaOx), with dietary excess a risk factor. Because …

Even though the prevalence of nephrolithiasis is increasing, our understanding of the
pathophysiology has not kept pace and new therapeutic approaches have not emerged. The …

Calcium oxalate stone disease is the most common human urinary stone disease in the
Western Hemisphere. To understand different aspects of the disease, calcium oxalate …

Purpose: The limitations imposed by human clinical studies and mammalian models of
nephrolithiasis have hampered the development of effective medical treatments and …

Purpose: The availability of various transgenic and knockout mice provides an excellent
opportunity to better understand the pathophysiology of calcium oxalate stone disease …

Crystallization of salts in the urine is a process common to many mammals including
humans. The crystals are either harmlessly excreted as crystalluria particles or are retained …

Our own studies and those of others have shown that the incidence of calcium oxalate
stones and plaques is markedly increased by nephrotoxins. The possible role of oxalate as …

The establishment of an experimental animal model would be useful to study the
mechanism of kidney stone formation. A calcium kidney stone model in rats induced by …

Crystal retention is studied in a rat-model system as a possible mechanism for the etiology of
human nephrolithiasis. A crystal-inducing diet (CID) of ethylene glycol plus NH 4 Cl in their …