Cellular senescence is historically associated with cancer suppression and aging. Recently,
the reach of the senescence genetic program has been extended to include the ability of …

Senescence is a form of cell cycle arrest induced by stress such as DNA damage and
oncogenes. However, while arrested, senescent cells secrete a variety of proteins …

Cellular senescence is a stress response that elicits a permanent cell cycle arrest and
triggers profound phenotypic changes such as the production of a bioactive secretome …

“Cellular senescence” is a state in which cells undergo irreversible cell cycle arrest in
response to a variety of cellular stresses. Once cells senesce, they are strongly resistant to …

Cellular senescence is a process by which cells enter a state of permanent cell cycle arrest.
It is commonly believed to underlie organismal aging and age-associated diseases …

Introduction: Cellular senescence is a stable form of cell cycle exit. Though they no longer
divide, senescent cells remain metabolically active and secrete a plethora of proteins …

Cellular senescence is a process that results in irreversible cell-cycle arrest, and is thought
to be an autonomous tumor-suppressor mechanism. During senescence, cells develop …

Cellular senescence is an established tumour-suppressive mechanism that prevents the
proliferation of premalignant cells. However, several lines of evidence show that senescent …

Cellular senescence plays a critical role in tumorigenesis. Once thought of as a tissue
culture artefact by some researchers, senescence is now a major field of study. Although …

Simple Summary A fundamental feature of cellular senescence is the emergence of the
Senescence-Associated Secretory Phenotype (SASP), which represents a considerable …