Three new series of quinoline, quinolone, and benzimidazole derivatives were synthesized
and evaluated in vitro against Trypanosoma brucei gambiense. In the quinoline series, the …

The current chemotherapy for second stage human African trypanosomiasis is
unsatisfactory. A synthetic optimization study based on the lead antitrypanosomal compound …

In this paper, the design, synthesis and biological evaluation of a set of quinazoline-2, 4, 6-
triamine derivatives (1–9) as trypanocidal, antileishmanial and antiplasmodial agents are …

Human African trypanosomiasis is a vector-borne tropical disease of African origin.
Presently, due to human migration and climate change, the disease might present global …

Abstract Human African Trypanosomiasis (HAT) is a neglected tropical disease caused by
the parasitic protozoan Trypanosoma brucei (T. b.), and affects communities in sub-Saharan …

Human African trypanosomiasis (HAT) or sleeping sickness is caused by two subspecies of
Trypanosoma brucei, Trypanosoma brucei gambiense, and Trypanosoma brucei …

Chagas' disease, caused by Trypanosoma cruzi (T. cruzi), is one of the most serious
parasitic diseases in Latin America. The currently available chemotherapy, based on …

Continuing with a program to develop new quinone derivatives as biologically active
compounds, we designed and synthesized a new series of aryloxy‐quinones, which were …

Chagas disease is an illness caused by the protozoan parasite Trypanosoma cruzi. The
current chemotherapy is based on benznidazole, and, in some countries, Nifurtimox, which …

The in vitro screening for trypanocidal activity against Trypanosoma brucei rhodesiense of
an in-house library of 62 compounds [ie alkane, diphenyl, and azaalkane bisguanidines and …