Pivotal research led by Louis Harold Gray in the 1950s suggested that oxygen plays a vital
role during radiotherapy. By proving that tumours have large necrotic cores due to hypoxia …

Since the initial observations made at the beginning of the last century, it has been
established that solid tumors contain regions of low oxygenation (hypoxia). Tumor cells can …

Regions of reduced oxygenation (hypoxia) are a characteristic feature of virtually all animal
and human solid tumours. Numerous preclinical studies, both in vitro and in vivo, have …

Hypoxia is present to some extent in most solid malignant human cancers because of an
imbalance between the limited oxygen delivery capacity of the abnormal vasculature and …

Hypoxia is an important factor in tumor biology and is both a predictive and a prognostic
factor in non–small cell lung cancer. The negative effect of low oxygenation on radiation …

Tumor hypoxia is a physiologic barrier to radiotherapy and anti-tumor drug delivery.
Numerous efforts have been made to overcome this barrier and to improve therapeutic …

Hypoxia has for many years been acknowledged to be a characteristic physiological
abnormality in solid tumours. It arises primarily because the tumour microcirculation that …

The results from many studies indicate that most solid tumors, regardless of site of origin,
contain hypoxic regions. Experimental studies have demonstrated that, apart from the well …

Tumor hypoxia or a reduction of the tissue oxygen tension is a key microenvironmental
factor for tumor progression and treatment resistance in solid tumors. Because hypoxic …

Highlights• Oxygen fixes DNA damage by free radicals and cells are 2–3 times more
radioresistant to sparsely ionising radiation when irradiated in the absence of oxygen.• OER …