How the histological structure of some lung cancers shaped almost 70 years of radiobiology
KR Worth, I Papandreou, EM Hammond - British Journal of Cancer, 2023 - nature.com
Pivotal research led by Louis Harold Gray in the 1950s suggested that oxygen plays a vital
role during radiotherapy. By proving that tumours have large necrotic cores due to hypoxia …
role during radiotherapy. By proving that tumours have large necrotic cores due to hypoxia …
The impact of hypoxia and its modification of the outcome of radiotherapy
MR Horsman, J Overgaard - Journal of radiation research, 2016 - academic.oup.com
Since the initial observations made at the beginning of the last century, it has been
established that solid tumors contain regions of low oxygenation (hypoxia). Tumor cells can …
established that solid tumors contain regions of low oxygenation (hypoxia). Tumor cells can …
[HTML][HTML] Therapeutic modification of hypoxia
MR Horsman, BS Sørensen, M Busk, DW Siemann - Clinical Oncology, 2021 - Elsevier
Regions of reduced oxygenation (hypoxia) are a characteristic feature of virtually all animal
and human solid tumours. Numerous preclinical studies, both in vitro and in vivo, have …
and human solid tumours. Numerous preclinical studies, both in vitro and in vivo, have …
The clinical significance of hypoxia in human cancers
N Dhani, A Fyles, D Hedley, M Milosevic - Seminars in nuclear medicine, 2015 - Elsevier
Hypoxia is present to some extent in most solid malignant human cancers because of an
imbalance between the limited oxygen delivery capacity of the abnormal vasculature and …
imbalance between the limited oxygen delivery capacity of the abnormal vasculature and …
Hypoxia as a cause of treatment failure in non–small cell carcinoma of the lung
OT Brustugun - Seminars in radiation oncology, 2015 - Elsevier
Hypoxia is an important factor in tumor biology and is both a predictive and a prognostic
factor in non–small cell lung cancer. The negative effect of low oxygenation on radiation …
factor in non–small cell lung cancer. The negative effect of low oxygenation on radiation …
[HTML][HTML] Targeting tumor hypoxia in radiotherapy: a brief review of historical background and recent progress
M Zhang, Z Zhou, Z Zhao… - Exploratory Research and …, 2016 - xiahepublishing.com
Tumor hypoxia is a physiologic barrier to radiotherapy and anti-tumor drug delivery.
Numerous efforts have been made to overcome this barrier and to improve therapeutic …
Numerous efforts have been made to overcome this barrier and to improve therapeutic …
Tumour hypoxia–a characteristic feature with a complex molecular background
JG Eriksen, MR Horsman - Radiotherapy and Oncology, 2006 - thegreenjournal.com
Hypoxia has for many years been acknowledged to be a characteristic physiological
abnormality in solid tumours. It arises primarily because the tumour microcirculation that …
abnormality in solid tumours. It arises primarily because the tumour microcirculation that …
Hypoxia and predicting radiation response
RP Hill, RG Bristow, A Fyles, M Koritzinsky… - Seminars in radiation …, 2015 - Elsevier
The results from many studies indicate that most solid tumors, regardless of site of origin,
contain hypoxic regions. Experimental studies have demonstrated that, apart from the well …
contain hypoxic regions. Experimental studies have demonstrated that, apart from the well …
Clinical biomarkers for hypoxia targeting
QT Le, D Courter - Cancer and Metastasis Reviews, 2008 - Springer
Tumor hypoxia or a reduction of the tissue oxygen tension is a key microenvironmental
factor for tumor progression and treatment resistance in solid tumors. Because hypoxic …
factor for tumor progression and treatment resistance in solid tumors. Because hypoxic …
Tumour hypoxia
CML West, F Slevin - 2019 - christie.openrepository.com
Highlights• Oxygen fixes DNA damage by free radicals and cells are 2–3 times more
radioresistant to sparsely ionising radiation when irradiated in the absence of oxygen.• OER …
radioresistant to sparsely ionising radiation when irradiated in the absence of oxygen.• OER …