Blockade of epidermal growth factor receptor signaling in tumor cells and tumor-associated endothelial cells for therapy of androgen-independent human prostate …
SJ Kim, H Uehara, T Karashima, DL Shepherd… - Clinical cancer …, 2003 - AACR
Purpose: We determined whether blockade of the epidermal growth factor receptor (EGF-R)
signaling pathway by oral administration of the EGF-R tyrosine kinase inhibitor (PKI 166) …
signaling pathway by oral administration of the EGF-R tyrosine kinase inhibitor (PKI 166) …
Blockade of epidermal growth factor receptor signaling leads to inhibition of renal cell carcinoma growth in the bone of nude mice
KL Weber, M Doucet, JE Price, C Baker, SJ Kim… - Cancer Research, 2003 - AACR
Renal cell carcinoma (RCC) frequently produces metastases to the musculoskeletal system
that are a major source of morbidity in the form of pain, immobilization, fractures …
that are a major source of morbidity in the form of pain, immobilization, fractures …
Dual inhibition of the epidermal growth factor and vascular endothelial growth factor phosphorylation for antivascular therapy of human prostate cancer in the prostate …
S Yazici, SJ Kim, JE Busby, J He, P Thaker… - The …, 2005 - Wiley Online Library
BACKGROUND Androgen‐independent prostate cancer (PCa) may be susceptible to
modulation of the tumor microenvironment. We determined whether a dual tyrosine kinase …
modulation of the tumor microenvironment. We determined whether a dual tyrosine kinase …
Inhibition of angiogenesis by the antiepidermal growth factor receptor antibody ImClone C225 in androgen-independent prostate cancer growing orthotopically in …
T Karashima, P Sweeney, JW Slaton, SJ Kim… - Clinical cancer …, 2002 - AACR
In human androgen-independent prostate cancer (PCa), epidermal growth factor receptor
(EGFR) regulates angiogenesis, tumor growth, and progression. In this study, we evaluated …
(EGFR) regulates angiogenesis, tumor growth, and progression. In this study, we evaluated …
Simultaneous blockade of platelet-derived growth factor-receptor and epidermal growth factor-receptor signaling and systemic administration of paclitaxel as therapy …
Once prostate cancer metastasizes to bone, conventional chemotherapy is largely
ineffective. We hypothesized that inhibition of phosphorylation of the epidermal growth factor …
ineffective. We hypothesized that inhibition of phosphorylation of the epidermal growth factor …
Suppression of EGF-R signaling reduces the incidence of prostate cancer metastasis in nude mice
The activation of epidermal growth factor receptor (EGF-R) plays a key role in the promotion
of proliferation and invasion in prostatic carcinoma (PCa). Gefitinib (Iressa; ZD1839), an …
of proliferation and invasion in prostatic carcinoma (PCa). Gefitinib (Iressa; ZD1839), an …
Inhibition of chemomigration of a human prostatic carcinoma cell (TSU‐pr1) line by inhibition of epidermal growth factor receptor function
A Zolfaghari, D Djakiew - The Prostate, 1996 - Wiley Online Library
Chemoattractants expressed at bony sites and pelvic lymph nodes are thought to promote
the preferential metastasis of human prostate tumor cells to these organs. Epidermal growth …
the preferential metastasis of human prostate tumor cells to these organs. Epidermal growth …
Blockade of epidermal growth factor receptor signaling on tumor cells and tumor-associated endothelial cells for therapy of human carcinomas
CH Baker, D Kedar, MF McCarty, R Tsan… - The American journal of …, 2002 - Elsevier
The purpose of this study was to determine whether the expression of epidermal growth
factor receptor (EGF-R) and activated EGF-R by tumor-associated endothelial cells is …
factor receptor (EGF-R) and activated EGF-R by tumor-associated endothelial cells is …
EGF receptor signaling enhances in vivo invasiveness of DU-145 human prostate carcinoma cells
T Turnert, P Chen, LJ Goodly, A NWells - Clinical & experimental …, 1996 - Springer
Carcinomas of the prostate and other lineages often present an autocrine stimulatory loop
acting via the EGF receptor (EGFR). We have recently shown that EGFR-mediated signals …
acting via the EGF receptor (EGFR). We have recently shown that EGFR-mediated signals …
EGF receptor (EGFR) signaling promoting invasion is disrupted in androgen‐sensitive prostate cancer cells by an interaction between EGFR and androgen receptor …
L Bonaccorsi, V Carloni, M Muratori… - … Journal of Cancer, 2004 - Wiley Online Library
We previously demonstrated that expression of androgen receptor (AR) by transfection of
the androgen‐independent prostate cancer cell line PC3 decreases invasion and adhesion …
the androgen‐independent prostate cancer cell line PC3 decreases invasion and adhesion …