Robust immunity to intracellular infections is mediated by antigen-specific naive CD8 T cells
that become activated and differentiate into phenotypically and functionally diverse subsets …

The process by which naïve CD8 T cells become activated, accumulate, and terminally
differentiate as well as develop into memory cytotoxic T lymphocytes (CTLs) is central to the …

Immunity to intracellular pathogens and cancer relies on the generation of robust CD8+ T
cell effector responses as well as the establishment of immunological memory. During a …

In response to acute infections or vaccines, naive antigen‐specific CD8+ T cells proliferate
and differentiate into effector cytotoxic lymphocytes that acquire the ability to kill infected …

CD4+ T cells are critical for the elimination of an immense array of microbial pathogens.
Although there are aspects of helper T-cell differentiation that can be modeled as a classic …

Following antigen recognition, CD8+ T lymphocytes can follow different patterns of
differentiation, with the generation of different subsets characterized by distinct phenotypes …

The changes of transcription factor activity and chromatin dynamics guide functional
differentiation of T cell subsets, including commitment to short-lived effectors and long-term …

Immune protection and lasting memory are accomplished through the generation of
phenotypically and functionally distinct CD8 T cell subsets. Understanding how these …

The differentiation of memory CD8T cells after acute infections comprises generation of
functionally distinct populations that either have proliferative potential or display cytotoxic …

Memory differentiation of CD4 and CD8 T-cell populations has been extensively studied and
many key molecular players and transcriptional networks have been identified. But how …