Parity-dependent recognition of DBL1X-3X suggests an important role of the VAR2CSA high-affinity CSA-binding region in the development of the humoral response …

S Dechavanne, A Srivastava, S Gangnard… - Infection and …, 2015 - Am Soc Microbiol
Plasmodium falciparum multidomain protein VAR2CSA stands today as the leading vaccine
candidate against pregnancy-associated malaria (PAM). Most of the studies aiming to …

Antigen reversal identifies targets of opsonizing IgGs against pregnancy-associated malaria

LH Lambert, JL Bullock, ST Cook, K Miura… - Infection and …, 2014 - Am Soc Microbiol
Clinical immunity to pregnancy associated-malaria (PAM) in multigravida women has been
attributed to antibodies that recognize VAR2CSA on the infected erythrocyte (IE) surface …

Var2CSA DBL6-epsilon domain expressed in HEK293 induces limited cross-reactive and blocking antibodies to CSA binding parasites

P Fernandez, NK Viebig, S Dechavanne, C Lépolard… - Malaria Journal, 2008 - Springer
Background Pregnancy-associated malaria (PAM) is a serious consequence of Plasmodium
falciparum-infected erythrocytes sequestration in the placenta through the adhesion to the …

Several domains from VAR2CSA can induce Plasmodium falciparum adhesion-blocking antibodies

A Salanti, M Resende, SB Ditlev, VV Pinto, M Dahlbäck… - Malaria Journal, 2010 - Springer
Abstract Background Malaria caused by Plasmodium falciparum can result in several
different syndromes with severe clinical consequences for the about 200 million individuals …

Identification of VAR2CSA domain-specific inhibitory antibodies of the Plasmodium falciparum erythrocyte membrane protein 1 using a novel flow cytometry assay

H Obiakor, M Avril, NJ MacDonald… - Clinical and Vaccine …, 2013 - Am Soc Microbiol
ABSTRACT VAR2CSA, a member of the Plasmodium falciparum erythrocyte membrane
protein 1 (PfEMP1) family, is a leading candidate for use in vaccines to protect first-time …

Chondroitin sulfate A-adhering Plasmodium falciparum-infected erythrocytes express functionally important antibody epitopes shared by multiple variants

L Barfod, T Dobrilovic, P Magistrado… - The Journal of …, 2010 - journals.aai.org
Acquired protection from Plasmodium falciparum placental malaria, a major cause of
maternal, fetal, and infant morbidity, is mediated by IgG specific for the P. falciparum …

Optimizing expression of the pregnancy malaria vaccine candidate, VAR2CSA in Pichia pastoris

M Avril, MJ Hathaway, MM Cartwright, SO Gose… - Malaria Journal, 2009 - Springer
Background VAR2CSA is the main candidate for a vaccine against pregnancy-associated
malaria, but vaccine development is complicated by the large size and complex disulfide …

Multilaboratory approach to preclinical evaluation of vaccine immunogens for placental malaria

M Fried, M Avril, R Chaturvedi, P Fernandez… - Infection and …, 2013 - Am Soc Microbiol
Pregnancy malaria is caused by Plasmodium falciparum-infected erythrocytes that adhere to
the placental receptor chondroitin sulfate A (CSA) and sequester in the placenta; women …

[HTML][HTML] Characterization of anti-var2CSA-PfEMP1 cytoadhesion inhibitory mouse monoclonal antibodies

M Avril, B Gamain, C Lépolard, N Viaud, A Scherf… - Microbes and …, 2006 - Elsevier
Pregnancy-associated malaria (PAM) is associated with the massive sequestration of
erythrocytes infected with CSA-binding parasites in the placenta. Natural protective immunity …

[PDF][PDF] Antibodies among men and children to placental-binding Plasmodium falciparum-infected erythrocytes that express var2csa

JG Beeson, F Ndungu, KEM Persson… - The American journal …, 2007 - academia.edu
During pregnancy, specific variants of Plasmodium falciparum-infected erythrocytes (IEs)
can accumulate in the placenta through adhesion to chondroitin sulfate A (CSA) mediated …