Plasmodium falciparum malaria remains one of the world's leading causes of human
suffering and poverty. Each year, the disease takes 1–3 million lives, mainly in sub-Saharan …

Abstract Background Antigenic variation of Plasmodium falciparum erythrocyte membrane
protein 1 is a key parasite mechanism for immune evasion and parasite survival. It is …

Placental malaria (PM) is characterized by infected erythrocytes (IEs) that selectively bind to
chondroitin sulfate A (CSA) and sequester in placental tissue. Variant surface antigen 2-CSA …

The malaria parasite Plasmodium falciparum presents antigens on the infected erythrocyte
surface that bind human receptors expressed on the vascular endothelium. The VAR2CSA …

Malaria during pregnancy in Plasmodium falciparum endemic regions is a major cause of
mortality and severe morbidity. VAR2CSA is the parasite ligand responsible for …

Pregnancy-associated malaria is a severe clinical syndrome associated with the
sequestration of Plasmodium falciparum-infected erythrocytes in the placenta. Placental …

Clinical immunity to malaria is associated with the acquisition of IgG specific for members of
the Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family of clonally …

Over 30 million women living in P. falciparum endemic areas are at risk of developing
malaria during pregnancy every year. Placental malaria is characterized by massive …

In the Saimiri sciureus monkey, erythrocytes infected with the varO antigenic variant of the
Plasmodium falciparum Palo Alto 89F5 clone bind uninfected red blood cells (rosetting) …

People living in areas with stable transmission of P. falciparum parasites acquire protective
immunity to malaria over a number of years and following multiple disease episodes …