[HTML][HTML] Full-length recombinant Plasmodium falciparum VAR2CSA binds specifically to CSPG and induces potent parasite adhesion-blocking antibodies

P Khunrae, M Dahlbäck, MA Nielsen… - Journal of molecular …, 2010 - Elsevier
Plasmodium falciparum malaria remains one of the world's leading causes of human
suffering and poverty. Each year, the disease takes 1–3 million lives, mainly in sub-Saharan …

[HTML][HTML] Antibody responses to the full-length VAR2CSA and its DBL domains in Cameroonian children and teenagers

BAY Fodjo, N Atemnkeng, L Esemu, EK Yuosembom… - Malaria Journal, 2016 - Springer
Abstract Background Antigenic variation of Plasmodium falciparum erythrocyte membrane
protein 1 is a key parasite mechanism for immune evasion and parasite survival. It is …

Antibodies to Escherichia coli-expressed C-terminal domains of Plasmodium falciparum variant surface antigen 2-chondroitin sulfate A (VAR2CSA) inhibit binding of …

T Saveria, AV Oleinikov, K Wiliamson… - Infection and …, 2013 - Am Soc Microbiol
Placental malaria (PM) is characterized by infected erythrocytes (IEs) that selectively bind to
chondroitin sulfate A (CSA) and sequester in placental tissue. Variant surface antigen 2-CSA …

Novel adenovirus encoded virus-like particles displaying the placental malaria associated VAR2CSA antigen

AMC Andersson, M Resende, A Salanti, MA Nielsen… - Vaccine, 2017 - Elsevier
The malaria parasite Plasmodium falciparum presents antigens on the infected erythrocyte
surface that bind human receptors expressed on the vascular endothelium. The VAR2CSA …

[HTML][HTML] Identification and characterization of B-cell epitopes in the DBL4ε domain of VAR2CSA

SB Ditlev, MA Nielsen, M Resende, MØ Agerbæk… - 2012 - journals.plos.org
Malaria during pregnancy in Plasmodium falciparum endemic regions is a major cause of
mortality and severe morbidity. VAR2CSA is the parasite ligand responsible for …

Immunization with VAR2CSA-DBL5 Recombinant Protein Elicits Broadly Cross-Reactive Antibodies to Placental Plasmodium falciparum-Infected Erythrocytes

M Avril, MM Cartwright, MJ Hathaway… - Infection and …, 2010 - Am Soc Microbiol
Pregnancy-associated malaria is a severe clinical syndrome associated with the
sequestration of Plasmodium falciparum-infected erythrocytes in the placenta. Placental …

IgG responses to the Plasmodium falciparum antigen VAR2CSA in Colombia are restricted to pregnancy and are not induced by exposure to Plasmodium vivax

M Lopez-Perez, MD Larsen, R Bayarri-Olmos… - Infection and …, 2018 - Am Soc Microbiol
Clinical immunity to malaria is associated with the acquisition of IgG specific for members of
the Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family of clonally …

[HTML][HTML] VAR2CSA-Mediated host defense evasion of Plasmodium falciparum infected erythrocytes in placental malaria

A Tomlinson, JP Semblat, B Gamain… - Frontiers in …, 2021 - frontiersin.org
Over 30 million women living in P. falciparum endemic areas are at risk of developing
malaria during pregnancy every year. Placental malaria is characterized by massive …

An In Vivo and In Vitro Model of Plasmodium falciparum Rosetting and Autoagglutination Mediated by varO, a Group A var Gene Encoding a Frequent Serotype

I Vigan-Womas, M Guillotte, C Le Scanf… - Infection and …, 2008 - Am Soc Microbiol
In the Saimiri sciureus monkey, erythrocytes infected with the varO antigenic variant of the
Plasmodium falciparum Palo Alto 89F5 clone bind uninfected red blood cells (rosetting) …

VAR2CSA and protective immunity against pregnancy-associated Plasmodium falciparum malaria

L Hviid, A Salanti - Parasitology, 2007 - cambridge.org
People living in areas with stable transmission of P. falciparum parasites acquire protective
immunity to malaria over a number of years and following multiple disease episodes …