Background Protection against pregnancy associated malaria (PAM) is associated with high
levels of anti-VAR2CSA antibodies. This protection is obtained by the parity dependent …

Pregnancy-associated malaria (PAM) is a serious consequence of sequestration of
Plasmodium falciparum-parasitized erythrocytes (PE) in the placenta through adhesion to …

Otherwise clinically immune women in areas endemic for malaria are highly susceptible to
Plasmodium falciparum malaria during their first pregnancy. Pregnancy-associated malaria …

Many pathogens evolve extensive genetic variation in virulence proteins as a strategy to
evade host immunity. This poses a significant challenge for the host to develop broadly …

Maternal malaria is associated with the sequestration, in the placenta, of Plasmodium
falciparum-infected erythrocytes onto chondroitin sulfate A (CSA), via the duffy binding-like …

Molecular interactions between the VAR2CSA protein, expressed on the surface of
Plasmodium falciparum-infected erythrocytes, and placental chondroitin sulfate A (CSA) are …

Background Pregnancy-associated malaria (PAM) is a serious consequence of the
adhesion to the placental receptor chondroitin sulfate A (CSA) of Plasmodium falciparum …

Malaria is a major global health problem. Pregnant women are susceptible to infection
regardless of previously acquired immunity. Placental malaria is caused by parasites …

Plasmodium falciparum parasites that bind to chondroitin sulphate A (CSA) express unique
variant surface antigens that are involved in the placental sequestration that precipitates …

In pregnant women, Plasmodium falciparum-infected erythrocytes expressing the VAR2CSA
antigen bind to chondroitin sulfate A in the placenta causing placental malaria. The binding …