Functional and immunological characterization of the var2CSA-DBL5ɛ domain of a placental Plasmodium falciparum isolate

S Gangnard, NGT Ndam, S Gnidehou… - Molecular and …, 2010 - Elsevier
Pregnancy-associated malaria (PAM) arises from sequestration of Plasmodium falciparum-
parasitized erythrocytes (PE) in the placenta, leading to chronic symptoms in the expectant …

Preclinical assessment of the receptor-binding domain of Plasmodium vivax Duffy-binding protein as a vaccine candidate in rhesus macaques

A Moreno, I Caro-Aguilar, SS Yazdani, AR Shakri… - Vaccine, 2008 - Elsevier
The receptor-binding domain of Plasmodium vivax Duffy-binding protein, region II (PvRII), is
an attractive candidate for a vaccine against P. vivax malaria. Here, we have studied the …

Molecular architecture and domain arrangement of the placental malaria protein VAR2CSA suggests a model for carbohydrate binding

MC Bewley, L Gautam, MG Jagadeeshaprasad… - Journal of Biological …, 2020 - ASBMB
VAR2CSA is the placental-malaria–specific member of the antigenically variant Plasmodium
falciparum erythrocyte membrane protein 1 (PfEMP1) family. It is expressed on the surface of …

Structure of the DBL3X-DBL4ε region of the VAR2CSA placental malaria vaccine candidate: insight into DBL domain interactions

S Gangnard, A Lewit-Bentley, S Dechavanne… - Scientific reports, 2015 - nature.com
The human malaria parasite, Plasmodium falciparum, is able to evade spleen-mediated
clearing from blood stream by sequestering in peripheral organs. This is due to the adhesive …

Naturally Acquired and Vaccine-Elicited Antibodies Block Erythrocyte Cytoadherence of the Plasmodium vivaxDuffy Binding Protein

P Michon, T Fraser, JH Adams - Infection and immunity, 2000 - Am Soc Microbiol
Malaria merozoites require the presence of specific surface receptors on the red blood cell
for invasion. Plasmodium vivax, requires the Duffy blood group antigen as an obligate …

Prospects and Pitfalls of Pregnancy‐Associated Malaria Vaccination Based on the Natural Immune Response to Plasmodium falciparum VAR2CSA‐Expressing …

EG Kane, AW Taylor-Robinson - Malaria Research and …, 2011 - Wiley Online Library
Pregnancy‐associated malaria, a manifestation of severe malaria, is the cause of up to
200,000 infant deaths a year, through the effects of placental insufficiency leading to growth …

Evidence for the involvement of VAR2CSA in pregnancy-associated malaria

A Salanti, M Dahlbäck, L Turner, MA Nielsen… - The Journal of …, 2004 - rupress.org
In Plasmodium falciparum–endemic areas, pregnancy-associated malaria (PAM) is an
important health problem. The condition is precipitated by accumulation of parasite-infected …

Evaluating antibody functional activity and strain-specificity of vaccine candidates for malaria in pregnancy using in vitro phagocytosis assays

M Hommel, JA Chan, AJ Umbers, C Langer… - Parasites & vectors, 2018 - Springer
Background Malaria in pregnancy is a major cause of poor maternal and infant health, and
is associated with the sequestration of P. falciparum-infected erythrocytes (IE) in the …

Epitope mapping and topographic analysis of VAR2CSA DBL3X involved in P. falciparum placental sequestration

M Dahlbäck, TS Rask, PH Andersen, MA Nielsen… - PLoS …, 2006 - journals.plos.org
Pregnancy-associated malaria is a major health problem, which mainly affects primigravidae
living in malaria endemic areas. The syndrome is precipitated by accumulation of infected …

Common Surface-Antigen var Genes of Limited Diversity Expressed by Plasmodium falciparum Placental Isolates Separated by Time and Space

A Khattab, PG Kremsner… - The Journal of infectious …, 2003 - academic.oup.com
Plasmodium falciparum placental parasites from Cameroon have been shown to express
surface variant var genes encoding Duffy binding–like (DBL)–γ domains that bind …