Functional and immunological characterization of the var2CSA-DBL5ɛ domain of a placental Plasmodium falciparum isolate
S Gangnard, NGT Ndam, S Gnidehou… - Molecular and …, 2010 - Elsevier
Pregnancy-associated malaria (PAM) arises from sequestration of Plasmodium falciparum-
parasitized erythrocytes (PE) in the placenta, leading to chronic symptoms in the expectant …
parasitized erythrocytes (PE) in the placenta, leading to chronic symptoms in the expectant …
Preclinical assessment of the receptor-binding domain of Plasmodium vivax Duffy-binding protein as a vaccine candidate in rhesus macaques
The receptor-binding domain of Plasmodium vivax Duffy-binding protein, region II (PvRII), is
an attractive candidate for a vaccine against P. vivax malaria. Here, we have studied the …
an attractive candidate for a vaccine against P. vivax malaria. Here, we have studied the …
Molecular architecture and domain arrangement of the placental malaria protein VAR2CSA suggests a model for carbohydrate binding
MC Bewley, L Gautam, MG Jagadeeshaprasad… - Journal of Biological …, 2020 - ASBMB
VAR2CSA is the placental-malaria–specific member of the antigenically variant Plasmodium
falciparum erythrocyte membrane protein 1 (PfEMP1) family. It is expressed on the surface of …
falciparum erythrocyte membrane protein 1 (PfEMP1) family. It is expressed on the surface of …
Structure of the DBL3X-DBL4ε region of the VAR2CSA placental malaria vaccine candidate: insight into DBL domain interactions
S Gangnard, A Lewit-Bentley, S Dechavanne… - Scientific reports, 2015 - nature.com
The human malaria parasite, Plasmodium falciparum, is able to evade spleen-mediated
clearing from blood stream by sequestering in peripheral organs. This is due to the adhesive …
clearing from blood stream by sequestering in peripheral organs. This is due to the adhesive …
Naturally Acquired and Vaccine-Elicited Antibodies Block Erythrocyte Cytoadherence of the Plasmodium vivaxDuffy Binding Protein
Malaria merozoites require the presence of specific surface receptors on the red blood cell
for invasion. Plasmodium vivax, requires the Duffy blood group antigen as an obligate …
for invasion. Plasmodium vivax, requires the Duffy blood group antigen as an obligate …
Prospects and Pitfalls of Pregnancy‐Associated Malaria Vaccination Based on the Natural Immune Response to Plasmodium falciparum VAR2CSA‐Expressing …
EG Kane, AW Taylor-Robinson - Malaria Research and …, 2011 - Wiley Online Library
Pregnancy‐associated malaria, a manifestation of severe malaria, is the cause of up to
200,000 infant deaths a year, through the effects of placental insufficiency leading to growth …
200,000 infant deaths a year, through the effects of placental insufficiency leading to growth …
Evidence for the involvement of VAR2CSA in pregnancy-associated malaria
In Plasmodium falciparum–endemic areas, pregnancy-associated malaria (PAM) is an
important health problem. The condition is precipitated by accumulation of parasite-infected …
important health problem. The condition is precipitated by accumulation of parasite-infected …
Evaluating antibody functional activity and strain-specificity of vaccine candidates for malaria in pregnancy using in vitro phagocytosis assays
M Hommel, JA Chan, AJ Umbers, C Langer… - Parasites & vectors, 2018 - Springer
Background Malaria in pregnancy is a major cause of poor maternal and infant health, and
is associated with the sequestration of P. falciparum-infected erythrocytes (IE) in the …
is associated with the sequestration of P. falciparum-infected erythrocytes (IE) in the …
Epitope mapping and topographic analysis of VAR2CSA DBL3X involved in P. falciparum placental sequestration
M Dahlbäck, TS Rask, PH Andersen, MA Nielsen… - PLoS …, 2006 - journals.plos.org
Pregnancy-associated malaria is a major health problem, which mainly affects primigravidae
living in malaria endemic areas. The syndrome is precipitated by accumulation of infected …
living in malaria endemic areas. The syndrome is precipitated by accumulation of infected …
Common Surface-Antigen var Genes of Limited Diversity Expressed by Plasmodium falciparum Placental Isolates Separated by Time and Space
A Khattab, PG Kremsner… - The Journal of infectious …, 2003 - academic.oup.com
Plasmodium falciparum placental parasites from Cameroon have been shown to express
surface variant var genes encoding Duffy binding–like (DBL)–γ domains that bind …
surface variant var genes encoding Duffy binding–like (DBL)–γ domains that bind …