The development and maintenance of cocaine addiction depend heavily on learned reward-
environment associations that can induce drug-seeking behavior and relapse …

Drug reinforcement learning is relevant for the development of addiction. The present study
investigated how changes in the magnitude of drug‐unconditioned stimulus during …

The aim of this study was to investigate the intracellular responses associated with the
acquisition and expression of cocaine-context associations. ERK (extracellular regulated …

Relapse to drug use following prolonged periods of abstinence results, in part, from the
ability of contextual cues paired previously with self-administered drug to elicit drug craving …

Background: Substance use disorder emerges in a small proportion of drug users and has
the characteristics of a chronic relapsing pathology. Aims: Our study aimed to demonstrate …

Conditioned place preference (CPP) is widely used for evaluating the rewarding effects of
drugs. Like other memories, CPP is proposed to undergo reconsolidation during which it is …

Rationale: In previous comparisons with C57BL/6J mice, DBA/2J mice have been
characterized as” hyporesponsive” to cocaine's rewarding effect in the conditioned place …

It is thought that rewarding experiences with drugs create strong contextual associations and
encourage repeated intake. In turn, repeated exposures to drugs of abuse make lasting …

Reinstatement of drug-seeking behavior in animals is relevant to drug relapse in humans. In
the present study, we employed the conditioned place preference (CPP) paradigm to …

Outbred, male Sprague–Dawley rats can be classified as either low or high cocaine
responders (LCRs or HCRs, respectively) based on cocaine-induced locomotor activity in an …