Analysis of CD20 and PD-L1 levels on small extracellular vesicles (sEV) produced by DLBCL cells and EBV-transformed B cells, and potential role in T cell inhibition

H Akil, H Bentayeb, M Aitamer, C Vignoles… - … Hematology & Oncology, 2024 - Springer
Increasing evidence supports a role for small extracellular vesicles (sEV, including
exosomes) in Diffuse Large B-cell lymphoma (DLBCL) progression and resistance to …

Deciphering the role and the mechanism of B-cell Non-Hodgkin Lymphoma-derived small Extracellular Vesicles in modulating the phenotype of myeloid cells.

M Bordas - 2023 - archiv.ub.uni-heidelberg.de
Non-Hodgkin Lymphomas (NHL) represent one of the most common cancers worldwide.
Among the most common forms of NHL are found Chronic Lymphocytic Leukemia (CLL) …

CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles

M Aitamer, H Akil, C Vignoles, M Branchaud… - British Journal of …, 2021 - nature.com
Background Small extracellular vesicles (sEVs) including exosomes, carrying the CD20,
could be involved in immunotherapy resistance in diffuse large B cell lymphoma (DLBCL) …

Clinical significance of plasma PD-L1+ exosomes in the management of diffuse large B cell lymphoma

P Xu, J Liu, H Chen, L Shang, F Wang, Y Zhu… - Annals of …, 2023 - Springer
PD-L1+ exosome have been reported to be a promising prognostic biomarker in various
cancers. However, its clinical value in diffuse large B cell lymphoma (DLBCL) has not been …

Universal extracellular vesicles and PD-L1+ extracellular vesicles detected by single molecule array technology as circulating biomarkers for diffuse large B cell …

JW Li, D Shi, XC Wan, J Hu, YF Su, YP Zeng… - …, 2021 - Taylor & Francis
Plasma extracellular vesicles (EVs) have been reported to be a promising source of
diagnostic and prognostic biomarkers in various cancers. However, further research in this …

Extracellular vesicles in DLBCL provide abundant clues to aberrant transcriptional programming and genomic alterations

SC Rutherford, AA Fachel, S Li, S Sawh… - Blood, The Journal …, 2018 - ashpublications.org
The biological role of extracellular vesicles (EVs) in diffuse large B-cell lymphoma (DLBCL)
initiation and progression remains largely unknown. We characterized EVs secreted by 5 …

Plasma extracellular vesicles bearing PD-L1, CD40, CD40L or TNF-RII are significantly reduced after treatment of AIDS-NHL

LE Martínez, S Lensing, D Chang, LI Magpantay… - Scientific reports, 2022 - nature.com
Emerging evidence shows that tumor cells secrete extracellular vesicles (EVs) that carry
bioactive cell surface markers, such as programmed death-ligand 1 (PD-L1), which can …

Diffuse large B cell lymphoma‐derived extracellular vesicles educate macrophages to promote tumours progression by increasing PGC‐1β

W Liu, M Zhu, H Wang, W Wang… - Scandinavian Journal of …, 2020 - Wiley Online Library
Tumour‐associated macrophages (TAMs) comprise an important part of the tumour
microenvironment and play a key role in malignant tumours progression. Tumour‐derived …

Immunosuppressive effect of small extracellular vesicle PD-L1 is restricted by co-expression of CD80

JY Liu, ZL Yu, QY Fu, LZ Zhang, JB Li, M Wu… - British Journal of …, 2023 - nature.com
Abstract Background The PD-L1 on tumor cell-derived small extracellular vesicles (sEVs)
can suppress the proliferation and cytokine production of T cells. However, PD-L1 can also …

Autologous blood extracellular vesicles and specific CD4+ T-cell co-activation

D Neyrinck-Leglantier, M Tamagne… - Frontiers in …, 2022 - frontiersin.org
Extracellular vesicles (EVs), which are generated by cell membrane budding in diverse
cells, are present in variable numbers in the blood. An immunoregulatory role has been …