Extracellular vesicles containing PD-L1 contribute to CD8+ T-cell immune suppression and predict poor outcomes in small cell lung cancer

X Dou, Y Hua, Z Chen, F Chao… - Clinical and Experimental …, 2022 - academic.oup.com
Abstract Programmed death ligand-1 (PD-L1) is expressed on the surface of tumor cells and
binds to programmed cell death protein-1 (PD1) on the surface of T cells, leading to cancer …

Autologous blood extracellular vesicles and specific CD4+ T-cell co-activation

D Neyrinck-Leglantier, M Tamagne… - Frontiers in …, 2022 - frontiersin.org
Extracellular vesicles (EVs), which are generated by cell membrane budding in diverse
cells, are present in variable numbers in the blood. An immunoregulatory role has been …

Canine B Cell Lymphoma-and Leukemia-Derived Extracellular Vesicles Moderate Differentiation and Cytokine Production of T and B Cells In Vitro

M Zmigrodzka, O Witkowska-Pilaszewicz… - International Journal of …, 2022 - mdpi.com
Extracellular vesicles (EVs) are formed in physiological and pathological conditions by
almost all mammalian cells. They are known as submicron “molecules” that transport and …

[HTML][HTML] DLBCL-derived exosomes provide key insights into genomic landscape in cell of origin and may lead to a novel method of surveillance and therapeutic …

SC Rutherford, A Fachel, S Li, Y Jiang, MP Dominguez… - Blood, 2017 - Elsevier
Disease monitoring with liquid biopsy would be particularly useful in diffuse large B-cell
lymphoma (DLBCL), an aggressive hematologic malignancy with poor outcomes in a …

Exosomes and extracellular vesicles as liquid biopsy biomarkers in diffuse large B‐cell lymphoma: Current state of the art and unmet clinical needs

K Ofori, G Bhagat, AJ Rai - British Journal of Clinical …, 2021 - Wiley Online Library
Diffuse large B‐cell lymphoma (DLBCL) is the most common type of non‐Hodgkin's
lymphoma, and it constitutes biologically heterogeneous entities. Standard first‐line …

[HTML][HTML] The multifaceted roles of extracellular vesicles for therapeutic intervention with non-Hodgkin lymphoma

AA Lee, AK Godwin, H Abdelhakim - Extracellular Vesicles and …, 2024 - oaepublish.com
Extracellular vesicles (EVs) contribute to the development of cancer in various ways. Non-
Hodgkin lymphoma (NHL) is a cancer of mature lymphocytes and the most common …

Extensive surface protein profiles of extracellular vesicles from cancer cells may provide diagnostic signatures from blood samples

L Belov, KJ Matic, S Hallal, OG Best… - Journal of …, 2016 - Taylor & Francis
Extracellular vesicles (EV) are membranous particles (30–1,000 nm in diameter) secreted by
cells. Important biological functions have been attributed to 2 subsets of EV, the exosomes …

Extracellular vesicles in diffuse large B cell lymphoma: characterization and diagnostic potential

R Matthiesen, P Gameiro, A Henriques, C Bodo… - International Journal of …, 2022 - mdpi.com
Diffuse large B cell lymphoma (DLBCL) is an aggressive B cell lymphoma characterized by
a heterogeneous behavior and in need of more accurate biological characterization …

[PDF][PDF] The impact of diffuse large B-cell lymphoma-derived exosomes on macrophage polarisation and cytokine release

H Ling, Z Yang, Y Sun, Y He, S Ju, J Li… - Arch Med …, 2020 - archivesofmedicalscience.com
Introduction: The pro-tumoural role of M2 macrophages has been described in various
cancers and is associated with poor clinical outcomes. Exosomes derived from cancers can …

Specific decrease in B-cell-derived extracellular vesicles enhances post-chemotherapeutic CD8+ T cell responses

F Zhang, R Li, Y Yang, C Shi, Y Shen, C Lu, Y Chen… - Immunity, 2019 - cell.com
Systemic immunosuppression greatly affects the chemotherapeutic antitumor effect. Here,
we showed that CD19+ extracellular vesicles (EVs) from B cells through CD39 and CD73 …