Biological evaluation and molecular docking studies of 4-aminobenzohydrazide derivatives as cholinesterase inhibitors
Nowadays, inhibition of the acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)
enzymes have emerged as an encouraging approach in the treatment of dementia and …
enzymes have emerged as an encouraging approach in the treatment of dementia and …
Synthesis, in silico and in vitro studies of hydrazide‐hydrazone imine derivatives as potential cholinesterase inhibitors
SA Güngör - Chemical Biology & Drug Design, 2023 - Wiley Online Library
A series of hydrazide‐hydrazone imine derivative compounds (3a–k) were synthesized and
their structures characterized using FTIR, 1H, and 13C (NMR) spectroscopic methods. In …
their structures characterized using FTIR, 1H, and 13C (NMR) spectroscopic methods. In …
A series of new hydrazone derivatives: Synthesis, molecular docking and anticholinesterase activity studies
Background: Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are known to
be serine hydrolase enzymes responsible for the hydrolysis of acetylcholine (ACh), which is …
be serine hydrolase enzymes responsible for the hydrolysis of acetylcholine (ACh), which is …
[HTML][HTML] Synthesis and AChE-inhibitory activity of new benzimidazole derivatives
Alzheimer's disease (AD), one of the main causes of aged dementia, is a progressive and
degenerative neurological disorder characterized by loss of cognition and memory …
degenerative neurological disorder characterized by loss of cognition and memory …
In silico studies on 2, 3-dihydro-1, 5-benzothiazepines as cholinesterase inhibitors
FL Ansari, S Kalsoom, Z Ali, F Jabeen - Medicinal Chemistry Research, 2012 - Springer
In vitro studies on cholinesterase inhibitory potential on the three sets of 2, 3-dihydro-1, 5-
benzothiazepines have been carried out. The compounds in Set 1 were unsubstituted on …
benzothiazepines have been carried out. The compounds in Set 1 were unsubstituted on …
Bioactive sulfonyl hydrazones with alkyl derivative: Characterization, ADME properties, molecular docking studies and investigation of inhibition on choline esterase …
In this work, new sulfonylhydrazone compounds with alkyl derivatives (SH1–SH4 series)
were synthesized via a green chemistry method, and their inhibition effects on …
were synthesized via a green chemistry method, and their inhibition effects on …
Molecular docking and investigation of 4-(benzylideneamino)-and 4-(benzylamino)-benzenesulfonamide derivatives as potent AChE inhibitors
The discovery of acetylcholinesterase inhibitors is important for the treatment of Alzheimer's
disease (AD), known as the most common type of dementia. Due to the side effects of …
disease (AD), known as the most common type of dementia. Due to the side effects of …
Multifunctional cholinesterase inhibitors for Alzheimer's disease: Synthesis, biological evaluations, and docking studies of o/p‐propoxyphenylsubstituted‐1H …
G Sarıkaya, G Çoban, S Parlar… - Archiv der …, 2018 - Wiley Online Library
This study indicates the synthesis, cholinesterase (ChE) inhibitory activity, and molecular
modeling studies of 48 compounds as o‐and p‐(3‐substitutedethoxyphenyl)‐1H …
modeling studies of 48 compounds as o‐and p‐(3‐substitutedethoxyphenyl)‐1H …
Design, synthesis, evaluation and molecular modeling study of 4-N-phenylaminoquinolines for Alzheimer disease treatment
J Zhu, LN Wang, R Cai, SQ Geng, YF Dong… - Bioorganic & Medicinal …, 2019 - Elsevier
Dual binding site acetylcholinesterase (AChE) inhibitors and butyrylcholinesterase (BChE)
inhibitors have recently emerged as two classes of new anti-Alzheimer agents to positively …
inhibitors have recently emerged as two classes of new anti-Alzheimer agents to positively …
Synthesis, biological evaluation, theoretical investigations, docking study and ADME parameters of some 1, 4-bisphenylhydrazone derivatives as potent antioxidant …
I Amine Khodja, H Boulebd - Molecular Diversity, 2021 - Springer
Abstract Five 1, 4-bisphenylhydrazone derivatives (1–5) were successfully synthesized and
evaluated for their antioxidant and acetylcholinesterase inhibitory activities. The antioxidant …
evaluated for their antioxidant and acetylcholinesterase inhibitory activities. The antioxidant …
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