Adoptive transfer of regulatory T cells (Treg) can induce transplant tolerance in preclinical
models by suppressing alloantigen-directed inflammatory responses; clinical translation was …

Cellular therapies with polyclonal regulatory T-cells (Tregs) in transplantation and
autoimmune diseases have been carried out in both animal models and clinical trials …

Abstract Purpose of Review The adoptive transfer of alloantigen-specific regulatory T cells
(Tregs) following organ transplantation is an emerging treatment paradigm that may induce …

Regulatory T cells are critical for maintaining immune tolerance. Recent studies have
confirmed their therapeutic suppressive potential to modulate immune responses in organ …

Based on compelling evidence from a vast number of in vitro and in vivostudies, Tregs have
become an attractive cell population to treat or even prevent auto-and alloimmunity …

Regulatory T cell (Treg) therapy using recipient-derived Tregs expanded ex vivo is currently
being investigated clinically by us and others as a means of reducing allograft rejection …

Adoptive regulatory T-cell (Treg) therapy using autologous Tregs expanded ex vivo is a
promising therapeutic approach which is currently being investigated clinically as a means …

Cell therapy with autologous donor-specific regulatory T cells (Tregs) is a promising strategy
to minimize immunosuppression in transplant recipients. Chimeric antigen receptor (CAR) …

A primary goal in transplantation medicine is the induction of a tolerogenic environment for
prevention of transplant rejection without the need for long-term pharmacological …

Solid organ transplantation is the treatment of choice for various end-stage diseases, but
requires the continuous need for immunosuppression to prevent allograft rejection. This …