An ovine model of spinal cord injury

S Wilson, KO Abode-Iyamah, JW Miller… - The journal of spinal …, 2017 - Taylor & Francis
Objective: To develop a large animal model of spinal cord injury (SCI), for use in
translational studies of spinal cord stimulation (SCS) in the treatment of spasticity. We seek …

Ovine hemisection model of spinal cord injury

S Wilson, DC Fredericks, S Safayi… - Journal of …, 2021 - Taylor & Francis
Introduction We are developing ovine models of spinal cord injury to test novel
neuromodulation-based methods on spasticity. The hemisection has been reported in a …

Spinal cord stimulation: therapeutic benefits and movement generation after spinal cord injury

CH Tator, K Minassian, VK Mushahwar - Handbook of clinical neurology, 2012 - Elsevier
Spinal cord injury (SCI) is a devastating neurological condition that leads to loss of motor
and sensory function. It commonly causes impairments in limb movements, respiration …

Kinematic analysis of the gait of adult sheep during treadmill locomotion: parameter values, allowable total error, and potential for use in evaluating spinal cord injury

S Safayi, ND Jeffery, SK Shivapour… - Journal of the …, 2015 - Elsevier
We are developing a novel intradural spinal cord (SC) stimulator designed to improve the
treatment of intractable pain and the sequelae of SC injury. In-vivo ovine models of …

Modification of spasticity by transcutaneous spinal cord stimulation in individuals with incomplete spinal cord injury

US Hofstoetter, WB McKay, KE Tansey… - The journal of spinal …, 2014 - Taylor & Francis
Context/objective To examine the effects of transcutaneous spinal cord stimulation (tSCS) on
lower-limb spasticity. Design Interventional pilot study to produce preliminary data. Setting …

Porcine Models of Spinal Cord Injury

CA Wathen, YG Ghenbot, AK Ozturk, DK Cullen… - Biomedicines, 2023 - mdpi.com
Large animal models of spinal cord injury may be useful tools in facilitating the development
of translational therapies for spinal cord injury (SCI). Porcine models of SCI are of particular …

Spinal cord stimulation for spasticity: historical approaches, current status, and future directions

SJ Nagel, S Wilson, MD Johnson, A Machado… - … : Technology at the …, 2017 - Elsevier
Introduction Millions of people worldwide suffer with spasticity related to irreversible damage
to the brain or spinal cord. Typical antecedent events include stroke, traumatic brain injury …

Transcutaneous spinal cord stimulation induces temporary attenuation of spasticity in individuals with spinal cord injury

US Hofstoetter, B Freundl, SM Danner… - Journal of …, 2020 - liebertpub.com
Epidural spinal cord stimulation (SCS) is currently regarded as a breakthrough procedure for
enabling movement after spinal cord injury (SCI), yet one of its original applications was for …

Altered patterns of reflex excitability, balance, and locomotion following spinal cord injury and locomotor training

PK Bose, J Hou, R Parmer, PJ Reier… - Frontiers in …, 2012 - frontiersin.org
Spasticity is an important problem that complicates daily living in many individuals with
spinal cord injury (SCI). While previous studies in human and animals revealed significant …

Epidural electrical stimulation of posterior structures of the human lumbosacral cord: 3. Control of spasticity

MM Pinter, F Gerstenbrand, MR Dimitrijevic - Spinal cord, 2000 - nature.com
Objectives: The purpose of this study was to evaluate the effect of spinal cord stimulation
(SCS) on severe spasticity of the lower limbs in patients with traumatic spinal cord injury …