Effect of lysine acetylsalicylate on aluminium accumulation and (Na+/K+) ATPase activity in rat brain cortex synaptosomes after aluminium ingestion

VS Silva, PP Gonçalves - Toxicology Letters, 2015 - Elsevier
Aluminium is neurotoxic in humans and has been implicated in several neurological
disorders. Chronic use of buffered aspirins, as aspegic, would likely constitute the major …

Comparative effects of aluminum and ouabain on synaptosomal choline uptake, acetylcholine release and (Na+/K+) ATPase

VS Silva, MA Nunes, JM Cordeiro, AI Calejo, S Santos… - Toxicology, 2007 - Elsevier
Closing the gap between adverse health effects of aluminum and its mechanisms of action
still represents a huge challenge. Cholinergic dysfunction has been implicated in neuronal …

Disruption of neuronal calcium homeostasis after chronic aluminium toxicity in rats

A Kaur, KD Gill - Basic & Clinical pharmacology & toxicology, 2005 - Wiley Online Library
The present study was designed to investigate the possible effects of chronic aluminium
exposure on the various aspects of calcium homeostasis in rat brain. Chronic aluminium …

Lipid peroxidation facilitates aluminum accumulation in rat brain synaptosomes

FC Amador, MS Santos, CR Oliveira - Journal of Toxicology and …, 1999 - Taylor & Francis
Aluminum, a metal without redox capacity in biological systems, potentiates the stimulation
of lipid peroxidation induced by Fe2+. In this study the interactions between aluminum and …

Accumulation of aluminum by primary cultured astrocytes from aluminum amino acid complex and its apoptotic effect

DA Aremu, S Meshitsuka - Brain research, 2005 - Elsevier
Aluminum salts or doses that are unlikely in the human system have been employed in
toxicity studies and much attention had been focused on the secondary target (neurons) of …

Aluminum accumulation and membrane fluidity alteration in synaptosomes isolated from rat brain cortex following aluminum ingestion: effect of cholesterol

VS Silva, JM Cordeiro, MJ Matos, CR Oliveira… - Neuroscience …, 2002 - Elsevier
In the present work, we studied the effect of cholesterol/phospholipid (CH/PL) molar ratio on
aluminum accumulation and aluminum-induced alteration of membrane fluidity in rat brain …

Silicon reduces aluminum accumulation in rats: relevance to the aluminum hypothesis of Alzheimer disease

M Bellés, DJ Sanchez, M Gómez… - Alzheimer Disease & …, 1998 - journals.lww.com
In recent years, a possible relation between the aluminum and silicon levels in drinking
water and the risk of Alzheimer disease (AD) has been established. It has been suggested …

Aluminium toxicity in the rat brain: histochemical and immunocytochemical evidence

B Platt, G Fiddler, G Riedel, Z Henderson - Brain research bulletin, 2001 - Elsevier
Although the neurotoxic actions of aluminium (Al) have been well documented, its
contribution to neurodegenerative diseases such as Alzheimer's disease remains …

Neuropathology of aluminum toxicity in rats (glutamate and GABA impairment)

SS Abd El-Rahman - Pharmacological Research, 2003 - Elsevier
To get better insights into the pathological and biochemical defects underlying aluminum
toxicity in brain tissue, we exposed male albino rats for 35 days to aluminum sulfate by …

Aluminum alters calcium transport in plasma membrane and endoplasmic reticulum from rat brain

WR Mundy, PRS Kodavanti… - Journal of …, 1994 - Wiley Online Library
Calcium is actively transported into intracellular organelles and out of the cytoplasm by
Ca2+/Mg2+‐ATPases located in the endoplasmic reticulum and plasma membranes. We …