Streptozotocin-induced insulin deficiency leads to development of behavioral deficits in rats

S Haider, S Ahmed, S Tabassum, Z Memon… - Acta Neurologica …, 2013 - Springer
Diabetes mellitus is one of the most common serious metabolic disorders in humans that
develops due to diminished production of insulin (type I) or resistance to its effect (type II and …

Effect of streptozotocin induced diabetes on rat hippocampus.

N Pamidi, SN BN - Bratislavske lekarske listy, 2012 - europepmc.org
Objective The present study was designed to evaluate the diabetes induced neuronal
damage in the hippocampus of the rat brain. Background Diabetes mellitus is an endocrine …

Central nervous system complications of diabetes in streptozotocin-induced diabetic rats: a histopathological and immunohistochemical examination

A Guven, O Yavuz, M Cam, C Comunoglu… - International Journal of …, 2009 - Taylor & Francis
Diabetes mellitus is a common, potentially serious metabolic disorder. Over the long term,
diabetes leads to serious consequences in a number of tissues, especially those that are …

Cognitive decline in STZ-3V rats is largely due to dysfunctional insulin signalling through the dentate gyrus

AS Shingo, T Kanabayashi, T Murase, S Kito - Behavioural brain research, 2012 - Elsevier
Recent epidemiological studies have associated type 2 diabetes mellitus with an increased
risk of developing Alzheimer's disease (AD). A dramatic decrease in glucose utilisation has …

Time-dependent impairments in learning and memory in Streptozotocin-induced hyperglycemic rats

A Ahmed, G Zeng, D Jiang, H Lin, M Azhar… - Metabolic brain …, 2019 - Springer
The sedentary lifestyle is responsible for the high prevalence of diabetes which also impairs
cognition including learning and memory. Various studies have highlighted the learning and …

[图书][B] Long-term abnormalities in brain glucose/energy metabolism after inhibition of the neuronal insulin receptor: implication of tau-protein

S Hoyer, H Lannert - 2007 - Springer
The triplicate intracerebroventricular (icv) application of the diabetogenic compound
streptozotocin (STZ) in low dosage was used in 1-year-old male Wistar rats to induce a …

Antidepressant effects of insulin in streptozotocin induced diabetic mice: modulation of brain serotonin system

D Gupta, Y Kurhe, M Radhakrishnan - Physiology & behavior, 2014 - Elsevier
Diabetes is a persistent metabolic disorder, which often leads to depression as a result of
the impaired neurotransmitter function. Insulin is believed to have antidepressant effects in …

[HTML][HTML] Differential change in cortical and hippocampal monoamines, and behavioral patterns in streptozotocin-induced type 1 diabetic rats

LW Lin, FS Tsai, WT Yang, SC Lai… - Iranian journal of …, 2018 - ncbi.nlm.nih.gov
Objective (s): Diabetes mellitus (DM) is a widespread metabolic disorder worldwide. Clinical
physicians have found diabetic patients have mild to middle cognitive dysfunction and an …

Increased oxidative stress in prefrontal cortex and hippocampus is related to depressive-like behavior in streptozotocin-diabetic rats

H de Morais, CP de Souza, LM da Silva… - Behavioural brain …, 2014 - Elsevier
Depression is a common comorbid in diabetic patients. The pathophysiologic mechanisms
that relate this comorbidity is not completely elucidated yet, although several lines of …

Brain effect of insulin and clonazepam in diabetic rats under depressive-like behavior

CAY Wayhs, CP Mescka, CS Vanzin, GS Ribas… - Metabolic brain …, 2013 - Springer
Diabetes mellitus is characterized by hyperglycemia resulting from defects on insulin
secretion, insulin action, or both. It has recently become clear that the central nervous …