The Akt serine/threonine kinase family is comprised of three highly homologous isoforms,
namely Akt1 (PKBα, OMIM: 164730), Akt2 (PKBβ, OMIM: 164731), and Akt3 (PKBγ, OMIM …

The phosphoinositide 3-kinase (PI3K) signaling pathway is one of the most frequently
altered pathways in human cancer and has a critical role in driving tumor initiation and …

The phosphatidylinositol‐3 kinase (PI3K)–AKT pathway is one of the most commonly
dysregulated pathways in all of cancer, with somatic mutations, copy number alterations …

Akt kinase is a serine threonine kinase that exists in three isoforms, located in different
chromosomes and has distinct sites of expression which orchestrates diverse cellular …

Members of the highly conserved and ubiquitously expressed pleiotropic CK1 family play
major regulatory roles in many cellular processes including DNA-processing and repair …

The serine-threonine kinase AKT, also known as protein kinase B (PKB), was identified in
1977 as the proto-oncogene of the v-Akt oncogenic murine thymoma virus. 1 Subsequent …

Over the past decade, protein kinase B (PKB, also termed Akt) has emerged as an important
signaling mediator between extracellular cues and modulation of gene expression …

Abstract PI3K/AKT signalling is commonly disrupted in human cancers, with AKT being a
central component of the pathway, influencing multiple processes that are directly involved …

Protein Kinase B (PKB), more commonly referred to as Akt, is a serine/threonine-specific
protein kinase. It is well established as a critical signaling node that regulates a myriad of …

Akt regulates critical cellular processes including cell survival and proliferation, glucose
metabolism, cell migration, cancer progression and metastasis through phosphorylation of a …